hyperphosphaturia


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hyperphosphaturia

[¦hī·pər‚fäs·fə′tu̇r·ē·ə]
(medicine)
An excess of phosphates in the urine. Also known as phosphaturia.
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The characteristic biochemical phenotype is hypophosphatemia, hyperphosphaturia, normal or low serum calcium, increased serum alkaline phosphatase, normal or increased serum PTH, normal serum 25-hydroxyvitamin-D, and low or normal serum 1,25-dihydroxyvitamin-D (9, 10).
The clinical onset is often insidious, and the proximal tubular damage caused by the crystals typically manifests with features of Fanconi syndrome, including normoglycemic glycosuria, aminoaciduria, hyperuricosuria, hyperphosphaturia, and type II renal tubular acidosis.
There is hypophosphatemia, hyperphosphaturia, and decreased concentrations of 1.
Hypophosphataemic rickets (HR) is a genetic disorder whereby there is reduced reabsorption of phosphate in renal tubules which in turn leads to chronic hyperphosphaturia and hypophosphataemia and usually normal or reduced vitamin D3 levels.
One study reported that 22% of patients on tenofovir developed at least 2 out of 6 features of proximal tubular dysfunction such as hyperaminoaciduria, glycosuria in the presence of normoglycaemia, and hyperphosphaturia.