Diagnostic testing usually reveals leukocytosis, hypercalcemia, hyperproteinemia
, and hypercholesterolemia.
The basic principle of potentiometry is the same in both methods, but the indirect method uses an assumption that makes its use flawed under conditions of hyperlipidemia or hyperproteinemia
Our case presented serum hyperproteinemia
and hypergammaglobulinemia, and an increase in fibrinogen and the ESR.
Serum immunoelectrophoresis did not reveal hyperproteinemia
Pseudohyponatremia, a laboratory artifact, can be caused by hyperlipidemia and hyperproteinemia
, which displaces water to produce falsely low sodium values when it is measured with indirect diluted ion-selective electrode methods (3).
1) Abnormalities noted in the plasma biochemical analysis were hyperproteinemia
IVIG THERAPY RESULTS IN POSTINFUSIONAL HYPERVISCOSITY AND PSEUDOHYPONATREMIA ATTRIBUTABLE TO HYPERPROTEINEMIA
Indirect ion-specific electrode measurement of electrolytes is the most commonly used method of electrolyte analysis, and hyperlipidemia and/or hyperproteinemia
will produce artificially low sodium concentrations, owing to the electrolyte exclusion effect (1).
accompanied by an increase in the concentration of either beta or gamma globulins and a decrease in albumin concentration has been described in birds with mycobacterial infections.
No interference was seen from hyperproteinemia
(mean total protein 87 g/L) or hyperlipidemia (mean triglycerides >6 mmol/L or LDL >2.
For example, lipemia and hyperproteinemia
can interfere with the indirect potentiometric measurement of sodium (3).
, hyperlipidemia, hypermagnesemia).