Central pro opiomelanocortin gene delivery results in hypophagia
, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.
Evidence of both hyper and hypophagia
leading to derangements in body weight during depression provides a conceptual understanding of leptin involvement in stress related behavioral changes [9,10, 11].
Among the topics are grooming behavior, marble burying and burrowing, ultrasonic vocalizations by infant mice as a ethological expression of separation anxiety, the tail-suspension test as a model for characterizing antidepressant activity, learned helplessness, novelty-induced hypophagia
, stress protocols and behavioral testing for acute and chronic social defeat, and mice models for the manic pole of bipolar disorder.
What is most interesting is that in animal models, damage to the ventromedial hypothalamus (VMH) leads to hyperphagia and increased appetite, while damage to the lateral hypothalamus (LH) causes hypophagia
and decreased appetite (Liu & Gold 2003).