Microdeletions in these three regions are associated with various spermatogenetic alterations including Sertoli cell-only syndrome (SCOS), maturation arrest, and hypospermatogenesis
1), men with hypospermatogenesis
with favorable testicular histopathology on testis biopsy done at the time of varicocele repair had the best chances of having motile sperm in the ejaculate compared to Sertoli-cell only syndrome or MA.
Varicocele: Relation between anoxia and hypospermatogenesis
Cytological Findings Indices Interpretation Most of native cell Sertoli index 50% or Normal seen below Spermatic index 50% or below Most of native cells Sertoli index above Hypospermatogenesis
seen 50% Spermatic index 50% or below Germ cells identified Sertoli index 50% or Maturation arrest only to a particular below Spermatic index level of maturation zero Germ cells identified Sertoli index above Maturation arrest only to a particular 50% Spermatic index +Hypospermatogeneis level of maturation zero Spermatozoa out Sertoli index 50% or Duct obstruction number other native below Spermatic index cells above 50% Sertoli cells only Sertoli index 100% Total atrophy/ seen Spermatic index zero Sertoli cell only syndrome
Studies have observed that testicular biopsies from infertile Nigerian men showed a variety of pathological conditions; the most prevalent was hypospermatogenesis
A: In one of our studies, we determined the reproductive hormones and morphological changes induced by mobile phone radiation and found that long-term exposure to mobile phone radiation leads to reduction in serum testosterone levels and cause hypospermatogenesis
and maturation arrest in the spermatozoa in the testis of albino rats.
, and hypertension).
BACKGROUND: In utero exposure to endocrine-disrupting chemicals may contribute to testicular dysgenesis syndrome (TDS), a proposed constellation of increasingly common male reproductive tract abnormalities (including hypospadias, cryptorchidism, hypospermatogenesis
, and testicular cancer).
In a group of 135 men, sperm were found in 51% of men with Sertoli-cell-only pattern, 83% in men with maturation arrest, and 100% of men with hypospermatogenesis
First, the production of spermatozoa may not be enough to trigger apoptosis in men with hypospermatogenesis
Results: the most frequent testicular histological finding was hypospermatogenesis
(61%), followed by maturation arrest (22%) and germ cell aplasia (17%).
In the cases where late pachytene substages were observed in this group, failure of spermatogenesis appeared as hypospermatogenesis
, with a reduction of all stages from spermatogonia to spermatids.