hypoxanthine


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hypoxanthine

[¦hī·pō′zan‚thēn]
(biochemistry)
C5H4ON4 An intermediate product derived from adenine in the hydrolysis of nucleic acid.
References in periodicals archive ?
is to conversion of hypoxanthine to xanthine and to uric acid, an interconvertible form, xanthine dehydrogenase, also exists and is responsible for conversion of NAD+ to NADH.
The increase in XOR activity would then promote lipid peroxidation because XOR is expressed on the luminal surface of the endothelium (binds to the vascular endothelium) in many organs and catalysis the conversion of hypoxanthine into urate in a process that generates [O2*.
Biphasic addition strategy of hypoxanthine and thymidine for improving monoclonal antibody production.
Allopurinol inhibits xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid.
Instead, the parasite must make purines indirectly, by using an enzyme called purine nucleoside phosphorylase (PNP) to make a purine precursor called hypoxanthine.
The mitochondrial membrane dysfunction leads to impaired ATP metabolism with increased production of purine degradation products such as adenosine, inosine, hypoxanthine and xanthine which are substrates for ADA and XO.
When oxygen is supplied during reperfusion, xanthine oxidase converts hypoxanthine to uric acid and superoxide radicals.
During these states ATP is converted into hypoxanthine by 4-steps reduction via adenosine monophosphate (AMP) (Figure 2).
These changes lead to accumulation of adenosine and of its breakdown products, xanthine and hypoxanthine, which can act as substrates for XO (26).
Some HPLC peaks were identified, such as creatinine, uric acid (the highest contribution), hypoxanthine, indoxyl sulphate and hippuric acid.