- antiidiotypic relationship of neurotropic autoantibodies in patients with mild closed head injury.
However, if the genotypes change drastically, as by introduction of a new idiotype
, a new assessment of mega-environments is needed.
Neutralizing ADAs block the idiotype
of the drug molecule directly or by steric hindrance, with sufficient strength to interfere with, or eliminate, the activity of the drug.
Instead, they reported that the foreign gene was not turned on in most of the cells, but rather it had somehow influenced the mouse's own genes to mimic the foreign gene's idiotype
In the upcoming meeting with the FDA regarding the design of the confirmatory registration study, Biovest anticipates exploring the use of a specific subtype of the idiotype
biomarker found in a retrospective analysis of the first Phase III clinical trial, BV301.
can provoke anti-idiotypes
, which in turn can provoke anti-idiotypes
that attach to the initial provoker as well as to the anti-idiotype
Duffey, added, "In contrast to the often complex and expensive methods used to manufacture cell-based autologous cancer vaccines, BiovaxID manufacture is relatively straight-forward: we rely upon a largely automated process that yields small-batches of a patient-specific idiotype
Bayer's personalised idiotype
vaccine for the treatment of Non-Hodgkin's-Lymphoma (NHL) is currently in Phase I clinical trials, and the cooperation is related to the development of a personalised Non-Hodgkin's-Lymphoma vaccine.
Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype
and carrier antigens.
Chief of the Lymphoma Therapeutics Section at NCI and the principal investigator of the MCL study, stated in an article published in Genetic Engineering & Biotechnology News (GEN), "We found that among MCL patients treated with a hybridoma-based idiotype
vaccine, patients who had T-cells that produced GM-CSF when exposed to tumor antigen had a significantly longer survival and delayed time to next treatment compared to patients who did not have GM-CSF producing T-cells.
We hypothesize that the interfering antibody in the Olympus ferritin assay is a natural antiidiotypic antibody that binds to a unique idiotype
on the rabbit antihuman ferritin antibody linked to latex (5).
The vaccine essentially trains the body's immune system to recognize the idiotype
as a foreign invader to trigger an immune response that delays or prevents cancer recurrence.