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The condition of having an abnormally small number of platelets in the circulating blood.



a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
Thrombopoietin-receptor agonists for primary immune thrombocytopenia.
Though bone marrow aspirate alone is usually sufficient in diagnosing nutritional anaemia most of the haematological malignancies and immune thrombocytopenia, we found bone marrow biopsy very useful in diagnosing Granulomatous inflammation, lymphomatous infiltrations, Myelofibrosis and Aplastic Anaemia.
The autoantibody associated immune dysfunction in chronic hepatitis C has been likened to that in chronic immune thrombocytopenia purpura5,9.
Key Words: Chronic lymphocytic leukemia (CLL), Autoimmune Hemolytic anemia (AIHA), Immune Thrombocytopenia (ITP).
Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomized, phase 3 study.
Immune thrombocytopenia (ITP) was defined as isolated thrombocytopenia with normal bone marrow morphology, adequate number of non dysplastic megakaryocytes, lack of splenomegaly, and the absence of any identifiable cause of secondary thrombocytopenia (e.
Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia.
Being diagnosed with Immune Thrombocytopenia (ITP) - a condition that means her blood doesn't clot properly - has left Bridie unable to play freely with other children unsupervised for fear she will get hurt.
Knowledge of immune thrombocytopenia purpura can assist the nurse in caring for an affected patient and providing the necessary information for effective selfcare.