Thrombocytopenia

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thrombocytopenia

[¦thräm·bō‚sīd·ō′pē·nē·ə]
(medicine)
The condition of having an abnormally small number of platelets in the circulating blood.

Thrombocytopenia

 

a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
Approach to the diagnosis and management of drug-induced immune thrombocytopenia.
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by platelet destruction caused by an antiplatelet autoantibody (usually IgG) that results in platelet phagocytosis by the reticulo endothelial system.
Treatment with megestrol acetate improves human immunodeficiency virus associated immune thrombocytopenia.
Immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and post-transfusion purpura.
A plethora of other obstetric management approaches to maternal immune thrombocytopenia have been advocated.
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Fifty-two contributed chapters begin with coverage of stem cells and haemopoiesis, erthropoiesis, iron metabolism and disorders of haem synthesis, iron overload, and megaloblastic anaemia; the collection concludes with primary immune thrombocytopenia, haemtological aspects of system disease, and of tropical diseases, and neonatal haematology.
Being diagnosed with Immune Thrombocytopenia (ITP) - a condition that means her blood has a failed clotting mechanism - has left Bridie unable to play with other children unsupervised for fear she will get hurt.
Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen.
Rituximab treatment of refractory fludarabine-associated immune thrombocytopenia in chronic lymphocytic leukemia.