Immunochemistry

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Immunochemistry

A discipline concerned both with the structure of antibody (immunoglobulin) molecules and with their ability to bind an apparently limitless number of diverse chemical structures (antigens); with the structure, organization, and rearrangement of the genes coding for the immunoglobulin molecules; and with the structure and function of molecules on the surface of animal cells, such as the transplantation (histocompatibility) antigens, which recognize antibodies and the thymus-derived lymphocytes mediating the cellular immune response. See Antigen, Immunoassay, Immunoglobulin, Radioimmunoassay, Transplantation biology

Immunochemistry

 

a branch of immunology that studies the chemical foundations of immunity. The principal problems of immunochemistry are the study of the structure and properties of immune proteins—antibodies—and natural and synthetic antigens, as well as the elucidation of the laws governing the interactions between these principal components of immunological reactions in various organisms. Immunochemical methods also find practical application, especially during the separation and purification of the active principles of vaccines and serums.

REFERENCES

Boyd, W. C. Vvedenie v immunokhimicheskuiu spetsifichnost’. Moscow, 1963. (Translated from English.)
Immunokhimicheskii analiz. Edited by L. A. Zil’ber. Moscow, 1968.
Kabat, E., and M. Mayer. Eksperimental’naia immunokhimiia. Moscow, 1968. (Translated from English).

immunochemistry

[¦im·yə·nō′kem·ə·strē]
(immunology)
A branch of science dealing with the chemical changes associated with immunity factors.
References in periodicals archive ?
Characterization of immunochemically nonreactive urinary albumin.
It detects immunochemically nonreactive albumin in addition to the immunoreactive albumin detected by conventional assays (7).
During the last 3 years, size-exclusion HPLC has been promoted to detect forms of albumin that are not reactive immunochemically (1, 2).
The contribution of Osicka and Comper (1) was to isolate the 66 500-Da immunochemically nonreactive albumin from diabetic urine by further purification by HPLC after removal of immunochemically reactive albumin on a column of immobilized anti-human albumin antibodies.
Immunochemically nonreactive albumin has also been found in urine from diabetic patients analyzed by HPLC, which is able to measure both immunoreactive albumin and immunochemically nonreactive albumin (total albumin) (2).
Whether the new form(s) of PTH identified immunochemically by D'Amour et al.
Since the first introduction of an immunochemically based method (6), other methods based on the selective solubilization of LDL particles have also been reported (7).
Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein.
The development and evaluation of cardiac troponin I immunoassays require purified and immunochemically stable antigen for the production of calibrators and controls.
The protein was specifically captured immunochemically and quantified with one of two biotin-labeled lectins binding particular sugars on the protein: wheat germ agglutinin (WGA), with affinity for sialic acid and Nacetylglucosamine, and Concanavalin A (Con A), which binds preferentially to mannose.
2]M can be immunochemically detected in male serum by immunoblotting but not by conventional immunoassays for PSA (6, 20).