Immunochemistry

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Immunochemistry

A discipline concerned both with the structure of antibody (immunoglobulin) molecules and with their ability to bind an apparently limitless number of diverse chemical structures (antigens); with the structure, organization, and rearrangement of the genes coding for the immunoglobulin molecules; and with the structure and function of molecules on the surface of animal cells, such as the transplantation (histocompatibility) antigens, which recognize antibodies and the thymus-derived lymphocytes mediating the cellular immune response. See Antigen, Immunoassay, Immunoglobulin, Radioimmunoassay, Transplantation biology

Immunochemistry

 

a branch of immunology that studies the chemical foundations of immunity. The principal problems of immunochemistry are the study of the structure and properties of immune proteins—antibodies—and natural and synthetic antigens, as well as the elucidation of the laws governing the interactions between these principal components of immunological reactions in various organisms. Immunochemical methods also find practical application, especially during the separation and purification of the active principles of vaccines and serums.

REFERENCES

Boyd, W. C. Vvedenie v immunokhimicheskuiu spetsifichnost’. Moscow, 1963. (Translated from English.)
Immunokhimicheskii analiz. Edited by L. A. Zil’ber. Moscow, 1968.
Kabat, E., and M. Mayer. Eksperimental’naia immunokhimiia. Moscow, 1968. (Translated from English).

immunochemistry

[¦im·yə·nō′kem·ə·strē]
(immunology)
A branch of science dealing with the chemical changes associated with immunity factors.
References in periodicals archive ?
In the case of immunochemically nonreactive albumin, cleavage of the albumin chain appears to proceed relatively normally, but release of the fragments is impaired.
The detection of immunochemically nonreactive albumin was found to precede increases of RIA values by a mean of 3.
The aim of the present study was to further characterize the immunochemically nonreactive albumin species present in human diabetic urine.
the sum of immunoreactive albumin + immunochemically nonreactive albumin) and RIA, which detects immunoreactive albumin only.
In addition, urines containing large amounts of immunochemically nonreactive albumin were analyzed after multiple (six) freeze/thaw cycles.
Total urinary albumin (immunoreactive albumin plus immunochemically nonreactive albumin) was determined by analyzing urine samples using an Agilent 1100 HPLC system (Agilent Technologies) (2, 3).
The protein was specifically captured immunochemically and quantified with one of two biotin-labeled lectins binding particular sugars on the protein: wheat germ agglutinin (WGA), with affinity for sialic acid and Nacetylglucosamine, and Concanavalin A (Con A), which binds preferentially to mannose.
2]M can be immunochemically detected in male serum by immunoblotting but not by conventional immunoassays for PSA (6, 20).
c], transferrin, albumin, al-acid glycoprotein, haptoglobin, IgG, IgM, and IgA were determined immunochemically on the population that was used to establish the reference intervals.
Some investigators [9-12] prefer to assess renin concentrations by mass measurement with immunochemical methods rather than measure renin activity, because the immunochemically determined concentration will not be influenced by physiological or pathological variations of the renin substrate, angiotensinogen [9, 10].
Prior to detection, analyte in the patient's blood is immunochemically labeled with fluorescent molecules.