epitope

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Related to immunodominant epitope: antigenic determinant, discontinuous epitope

epitope:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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epitope

[′ep·ə‚tōp]
(immunology)
The portion of the antigen molecule that determines its capacity to combine with the specific combining site of its corresponding antibody in an antigen-antibody interaction.
References in periodicals archive ?
Considering these findings, we produced and characterized three overlapping fragments containing the immunodominant epitopes of FHA including rFHA1 (from aa 1201 to aa 1584- a total of 384aa), rFHA2 (from aa 1545 to aa 1917- a total of 373aa) and rFHA3 (from aa 1878 to aa 2250- a total of 373aa).
Fairly strong responses were seen in the genomic areas coding for the immunodominant epitopes gag, pol, and env.
Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels.
The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hotspot.