36 SEMA4D sema domain, immunoglobulin domain (Ig), -0.
048 RND2, SEMA4D neurons Abbreviations: ACER2, alkaline ceramidase 2; FUT4, fucosyltransferase 4; GCNT1, glucosaminyl (N-acetyl) transferase 1, core 2; MAN1B1, mannosidase, alpha, class 1B, member 1; NEU1, sialidase 1 (lysosomal sialidase); RND2, Rho family GTPase 2; SEMA4D, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; SGPL1, sphingosine-1-phosphate lyase 1; ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 4; TNFAIP3, tumor necrosis factor, alpha-induced protein 3; TNFR1, tumor necrosis factor binding protein 1.
Jovine's team solved the structure of a mouse ZP-N region and found that the type of fold in the ZP-N is a twist on a protein shape called the immunoglobulin domain
, which is well-known for its presence in antibodies.
The researchers' findings appeared in the June 20, 2006, edition of the journal PLoS Biology under the title "AgDscam, a Hyper Variable Immunoglobulin Domain Containing Receptor of the Anopheles gambiae Innate Immune System.
Different combinations of immunoglobulin domains, which are coded by spliced exons, are used to produce a broad range of receptors.
According to the first article, Titin, the largest protein in the human body, acts like a spring that stretches the muscle cell or slackens them and its spring region has certain protein units, the so-called immunoglobulin domains, which are strung like pearls on a string.
Under stress conditions, for example in acute heart failure, the spring region is excessively stretched and the immunoglobulin domains unfold.