immunological memory


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Related to immunological memory: immunological tolerance

immunological memory

[‚im·yə·nə¦läj·ə·kəl ′mem·rē]
(immunology)
The capacity of the immune system to respond more rapidly and vigorously to the second contact with a specific antigen than to the primary contact.
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Thus the invading virus is destroyed and prevented from multiplying, and immunological memory is developed that prevents future infection.
This immunological memory explains the power of vaccines.
It also results in a sustained immunological memory response, meaning that those who receive a 'booster' with a different pandemic strain vaccine will gain a rapid protective response to the pandemic virus.
The need for continued or repeated immunization is a good indication of the need for a stronger CD4+ T cell response, as specific activation of this cell type is associated both with immunological memory as well as a robust early response to immunization.
What kinds of information are we missing to understand how the genome sequence specifies the differentiation and response of immune system cells and system behaviour, such as immunological memory and tolerance?