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immunosuppression |
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immunosuppressionSuppression of immunity with drugs, usually to prevent rejection of an organ transplant. Its aim is to allow the recipient to accept the organ permanently with no unpleasant side effects. In some cases the dosage can be reduced or even stopped without causing rejection. Other uses are in the treatment of certain autoimmune diseases and for prevention of erythroblastosis fetalis. Its main drawback is the increased risk of infection for the duration of treatment and of lymphoma in the case of long-term immunosuppression. |
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Animal studies have shown that colonized mice may transmit the organism to immunosuppressed mice (32). Among the 5 patients in whom the presence or absence of fungal invasion was not reported, 2 were immunosuppressed (1 case of diabetes and 1 case of bone marrow transplantation); the diabetic patient was treated with surgery alone and his outcome was not reported, and the post-transplant patient was treated with combined surgery and antifungal therapy but died of a related cause. Add chickenpox, shingles, the immunosuppressant drugs used by cancer and organ-transplant patients, along with the increasing number of immunosuppressed patients who have HIV and AIDS, and it's not hard to understand why we are now seeing a greater incidence of herpes infections. |
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immunosuppressed
