immunotoxin


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immunotoxin

[‚im·yə·nō′täk·sən]
(immunology)
Conjugate of antibody and toxic protein such that the specificity of the antibody molecule is combined with the cytotoxic property of the toxin.
References in periodicals archive ?
One of the biggest challenges for immunotoxin therapy is its potential immunogenicity, which can originate from either antibody part or toxin part.
Generally, different means have been exploited in T reg suppression by researchers such as chemical drugs (9,11,12), anti CD25 monoclonal anti body (13,14), immunotoxins [Denileukin diftitox (ONTAK) and LMB-2 (single chain fragment variable anti-tacfused with bacterial Pseudomonas exotoxin A)] (1,8,15) and anti T reg vaccination targeting FoxP3 (3).
According to the researchers, these findings, coupled with results from previous studies, suggest that treating certain HIV-infected people with a combination of antiretrovirals and an immunotoxin might help achieve sustained disease remission, in which HIV can be controlled or eliminated without a lifetime of antiretroviral therapy.
In recent years, technological progress allowed construction of MoAbs other than their classical forms: for example, conjugated with radionucleotides, immunotoxins, or bispecific antibodies.
We make the immunotoxin, do all the preclinical studies, file and get an IND (Investigational New Drug Application) with the FDA, and do the clinical study, all on-site.
Investigational studies are currently being carried out to test other approaches, including immunotoxin therapy and gene therapy.
If the disease still does not respond, antilymphocyte antibodies are sometimes tried, or an immunotoxin (e.
Targeted cytotoxic effect of anti-JL1 immunotoxin against a human leukemic cell line and its clinical implications.
Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies.
The immunotoxin review that features ONCONASE will appear in "Handbook of Therapeutic Antibodies" (Wiley-VCH, Weinheim, Germany: Volume 3), edited by Professor Stefan Dubel from the Technical University of Braunschweig (Braunschweig, Germany).
This has stalled the field a great deal," says immunotoxin investigator Daniel A.
The ricin A-chain has been used in immunotoxin therapy to treat cancer and autoimmune disorders (Ghetie and Vitetta, 1994).