inclusion-cell disease


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inclusion-cell disease

[iŋ′klü·zhən ‚sel ‚diz‚ēz]
(medicine)
A rare genetic disorder in which lysosomal hydrolases are transported out of the cell into the blood, rather than into the lysosome, resulting in the accumulation of undigested macromolecules within the lysosome. Abbreviated I-cell disease.
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References in periodicals archive ?
Bickels syndrome, mucolipidoses, cherry-red-spot-myoclonus syndrome, inclusion-cell disease, growth-hormone deficiency, idiopathic short stature, small for gestational age (SGA), acromegaly, AIDS-associated wasting and cachexia, growth failure from chronic renal insuffi ciency (CRI), Noonans syndrome, Prader-Willis syndrome, short stature homeobox (SHOX) defi ciency, Turners syndrome, obesity, type 1 and type 2 diabetes.