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Localized death of tissue that is caused by obstructed inflow of arterial blood. Also known as infarction.



a focus of organ or tissue necrosis resulting from an interruption of the blood supply to the area. The direct causes of infarcts are thrombosis, embolism, or spasm of the arteries feeding this tissue. Hypoxia is a decisive factor in the development of the tissue changes associated with an infarct.

There are three types: white, or ischemic, infarct, which is a zone of necrosis lacking in blood; red, or hemorrhagic, infarct, in which the zone of necrosis is saturated with excessive blood; and ischemic infarct with a hemorrhagic zone. The first and third types of infarct are generally formed in the heart, kidneys, and spleen, and the second in the lungs and intestine. An infarct may be conical (kidney, lungs) or irregular (heart, brain) in shape. Its consistency varies with the nature of the necrosis, which may be dry (myocardial infarct) or moist (cerebral infarct).

Infarcts cause profound changes in the organs affected. The dead areas are resorbed or organized, resulting in the formation of a cyst (in the brain) or a scar (in the heart muscle), or they may suppurate and liquefy (septic infarct). The size, location, and properties of an infarct determine whether the affected organ becomes weakened or loses its functions.


References in periodicals archive ?
Presuming that activators of the GDF15 gene are expressed before this time point, we established a cDNA expression library from day 3 infarcted mouse hearts.
Right ventricular mass was not increased in the infarcted animals and was not influenced by estrogen therapy (Table 2).
The endpoint of efficacy: the absolute changes in myocardial viability and perfusion of the infarcted region from baseline to four months.
An urgent orchidectomy was performed, with histology revealing an infarcted testis with localised abscess formation (Fig.
On contrast-enhanced scans, they appear as perfusion defects and are distributed in geographical or segmental pattern with patchy and heterogenous enhancement due to undisplaced vessels in infarcted areas.
Histopathological findings showed that there were infarcted zone with necrosis, edema and inflammatory cells in model group, while TPG groups showing cardiac fibers with mild necrosis, edema and inflammatory cells (Fig.
We suggest that when observed in patients with chest pain, a Tc-99m tetrofosmin reverse perfusion pattern should be regarded as a possible marker of tissue at risk in the context of an infarcted subendocardial area.
short- and long-axis inversion recovery delayed-enhancement sequences to identify infarcted myocardial tissue
Infusion of recombinant GDF-15 into infarcted myocardium suppresses the inflammatory response, also suggesting a counterregulatory cytokine role (33).
For the first time, they were able to combine the use of human repair cells that were conditioned during in-vitro culture to maximize their ability to revascularize and improve blood flow to the infarcted tissue with a fully biological composite scaffold designed to deliver these cells to the damaged heart.
A new abdominal CT showed an increase in the size of hepatic infarctions in the right liver, and puncture of the infarcted area revealed purulent material.
Specifically, a percentage of infarcted placental tissue was assessed based on gross examination of sliced placental discs.