infiltrate

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infiltrate

1. Pathol any substance that passes into and accumulates within cells, tissues, or organs
2. Pathol a local anaesthetic solution injected into the tissues to cause local anaesthesia

Infiltrate

 

an accumulation in bodily tissues of cellular elements admixed with blood and lymph. Inflammatory and tumorous infiltrates occur most often.

An inflammatory infiltrate consists chiefly of polymorphonuclear leukocytes (suppurative infiltrate), erythrocytes (hemorrhagic infiltrate), lymphoid cells (round cell infiltrate), and histiocytes and plasma cells (histiocyte-plasma cell infiltrate). These infiltrates may be resolved, may liquefy, or may undergo sclerosis and form caverns, abscesses, scars, and so forth.

A tumorous infiltrate consists of tumor cells of different kinds (carcinoma, sarcoma); it is a manifestation of the infiltrating growth of a tumor. When an infiltrate forms, the tissue enlarges, changes color, and becomes harder and sometimes painful. In surgical practice, an infiltrate is an induration that develops in tissues when they become saturated with an anesthetic.

V. V. SEROV

References in periodicals archive ?
The number of infiltrates that occurred on the medical unit was 11 pre-implementation and 5 post-implementation; surgical unit was 16 pre-implementation and 6 post-implementation.
In indeterminate leprosy, all the three (100%) cases showed mild nonspecific perivascular and periadnexal infiltrate and lymphocyte predominant infiltrate with presence of histiocytes, while one of the three (33.
This dense inflammatory infiltrate may lead pathologists to misdiagnose ICN as lymphoma, especially in older patients.
The patient's symptoms are also important when assessing corneal infiltrates.
Transbronchial lung biopsy revealed several perivascular polymorphic lymphoid infiltrates composed of numerous small and rare large immunoblastic cells (Figure 1, B).
Keratinocyte hyperproliferation, condensed dermal collagen, and mononuclear perivascular infiltrate increased with lymphedema stage, which suggested progressive chronic inflammation and fibrosis.
The underlying stroma featured dense fibrosis and a nonspecific lymphocytic infiltrate.
Immunohistochemical (IHC) staining for SFG Rickettsia demonstrated rickettsiae and rickettsial antigens in sections of heart, spleen, and kidney localized within and around vascular endothelial cells and reticuloendothelial cells, predominantly in areas associated with perivascular mononuclear inflammatory infiltrates (Figure 2).
In the tumor stage, localized cutaneous T-cell lymphoma is associated with large reactive lymphoid infiltrates around the periphery of the lymphoma, and repeat biopsies are often necessary to obtain adequate diagnostic tissue.
The brain demonstrated characteristic microglial nodules and perivascular lymphocytic infiltrates (4).
The pars pylorica region of the stomach had multifocal mucosal abscesses and moderate diffuse lymphoplasmacytic and heterophilic infiltrates of the lamina propria.