Influenza B virus NS1 protein inhibits
conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.
repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells.
Lab tests have demonstrated that AgION's technology is used effectively against a wide range of bacteria and fungi and naturally inhibits
microbial growth in food contact applications.
the vascular relaxation induced by acetylcholine in a concentration-dependent manner and that possible mechanisms are the inhibition of NO production in endothelial cells and the suppression of cGMP-dependent relaxation mechanisms in smooth muscles.
OTCBB:FMVR), announced today that preclinical studies show that its compound for shingles inhibits
viral infections exceptionally quickly and that when FV-100 is dosed orally, the active compound shows good dose dependent pharmacokinetics.
Paul Talalay and his coworkers at Johns Hopkins Medical Institutions in Baltimore surprised cancer researchers in 1992 when they isolated sulforaphane, a compound in broccoli and its botanical kin that inhibits
the development of cancer (SN: 3/21/92, p.
They bind and apparently inhibit
apoptosis-induced proteases, enzymes that chop up other proteins.
The shorter antisense polymers are able to gain entry into the more complex bacterial cell wall and inactivate the targeted gene but are too short to inhibit
ARIAD's preclinical kinase inhibitors fall into two classes: inhibitors of key mutant kinases that confer resistance to current therapies and compounds that inhibit
multiple pathways associated with cancer progression, such as metastasis, angiogenesis and survival.
The research, presented at the Gordon Research Conference "The Biology of Aging" in Ventura, California, demonstrated that the telomerase activators not only increased the proliferative capacity of cytotoxic (CD8+) T-cells and their ability to produce a virus-fighting molecule, gamma Interferon (IFN(gamma)), but also improved the ability of CD8+ cells from HIV-positive donors to inhibit
virus production in infected CD4+ T-cells.
Thalidomide's ability to inhibit
angiogenesis appears unrelated to its effects on the immune system, they assert.
Recent findings have shown that inhibiting gastrin not only inhibits
cell growth, proliferation and metastasis directly, but also "unblocks" a central pathway leading to cell-suicide (apoptosis).