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protease inhibitor |
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protease inhibitor (prō`tē-ās'), any of a class of drugs that interfere with replication of the AIDS AIDS or acquired immunodeficiency syndrome, fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. ..... Click the link for more information. virus (HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS . There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. ..... Click the link for more information. ), by blocking an enzyme (protease) necessary in the late stages of its reproduction. Clinical trials of the protease inhibitor indinavir have shown it to be especially beneficial in combination with the anti-HIV drugs AZT AZT or zidovudine (zīdō`vy ..... Click the link for more information. and 3TC, which act by blocking a different enzyme, reverse transcriptase. Saquinavir, the first member of the class to be marketed, was approved for use in 1995 by the Food and Drug Administration. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Babies exposed in the first trimester of their mother's pregnancy to blood pressure drugs called ACE inhibitors are at an increased risk of birth defects, according to a new study. Association of PDE-5 Inhibitor Use in Men With ED and Sexual Function of Female Partners, William Fisher, University of Western Ontario; Raymond C. Merck reported that its experimental integrase inhibitor MK-0518 reduced HIV viral load 98%, in a 10-day monotherapy trial in 28 treatment-naive volunteers. |
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