Cyclacel has a corporate alliance with AstraZeneca to develop a specific Cyclin Groove Inhibitor
(CGI) for cancer.
A closer look at the data reveals that ACE inhibitors
protected men from heart problems better than diuretics did, but that women gained equal protection from the two drugs, report Christopher M.
Metabolic (lipid and glucose) and morphologic (fat accumulation and fat atrophy) abnormalities have been associated with protease inhibitors
President and Chief Operating Officer of Panacos commented, "Bevirimat, our first-generation maturation inhibitor
, has shown the potential clinical value of maturation inhibitors
Continued reverse transcriptase inhibitor
therapy is sufficient to maintain short-term partial suppression of multi-drug resistant viremia.
Inhibition of the Pan-Bcl-2 Family by the Small Molecule GX15-070 Induces Apoptosis in Mantle Cell Lymphoma (MCL) Cells and Enhances the Activity of Two Proteasome Inhibitors
(NPI-0052 and Bortezomib), and Doxorubicin Chemotherapy" [Yazbeck, et al.
6) The researchers did not find protease inhibitor
resistance in that arm--and indeed, found less resistance to the nucleosides as well.
A study from Europe (Abstract 539) found that patients starting a second protease inhibitor
containing regimen experienced greater success if the second regimen was initiated at a lower viral load or higher CD4 T cell count, or if new NRTIs were added.
As drugs, efflux-pump inhibitors
aren't expected to have a significant antimicrobial effect on their own.
FibroGen is focused on the discovery and development of small molecule inhibitors
of HIF-PH for therapeutic benefit in multiple clinical settings.
It will probably be the next protease inhibitor
Friedlander of Brigham and Women's Hospital in Boston and his colleagues worked with mice harboring a gene for an inhibitor