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Bax, Bak, PUMA, Noxa) and repressing antiapoptotic Bcl-2 (B-cell leukemia) proteins (Bcl-2, Bcl-XL) and inhibitor of apoptosis protein (survivin) (Bartke et al. Inhibitor of apoptosis proteins are a family of apoptosis-suppressing proteins commonly overexpressed in human cancers. Michael Berendt, Aegera President and CEO, stated, "We are very excited about the possibility of a new treatment for this devastating disease, and continue to believe that the Inhibitor of Apoptosis protein family, discovered by our founders, plays a central role in multiple disease indications. |
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