interferon-gamma


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

interferon-gamma

[‚in·tər¦fir‚än ′gam·ə]
(immunology)
An interferon produced by T lymphocytes and large granular lymphocytes in response to foreign macromolecules.
References in periodicals archive ?
If you see that the interferon-gamma level is high, you can diagnose latent TB," Liu said.
Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation.
The Company has demonstrated the effectiveness of its pioneering scientific strategy, and securing patents for the use of therapeutic antibodies to interferon-gamma, by conducting investigational clinical trials treating patients suffering from rheumatoid arthritis, multiple sclerosis, corneal transplant rejection, uveitis and certain autoimmune skin conditions, including psoriasis and alopecia areata.
Over the past five years, however, we have made significant progress in terms of confirming our premise -- Treatment of the following diseases in humans with antibodies to interferon-gamma will be effective:
The derG treated mice had the highest level of Interferon-gamma as detected in sera after challenge, as well as the highest frequency of CD4+/Interferon-gamma+ T-cells in both spleens and livers.
The IL-12 appears to signal immune cells to make interferon-gamma, a chemical that instructs infected liver cells to destroy themselves and the parasites they contain.
Interleukin-6 decreased approximately 98% with Enbrel(R) as compared to approximately 82% with the Senesco siRNA and Interferon-gamma decreased approximately 93% with Enbrel(R) as compared to approximately 87% with Senesco's siRNA.
The report, titled "Activation of Interferon-gamma Inducing Factor Mediated by Interleukin-1 beta Converting Enzyme," is published in the January 10, 1997 issue of the journal Science.
His team ultimately traced the problem to interferon-gamma and tumor necrosis factor-alpha, compounds that trigger local production of nitric oxide.
The key purpose of this study is to provide further evidence that inhibiting overproduction of TNF-alpha, and other cytokines such as interferon-gamma and certain subtypes of interferon-alpha, implicated in stimulating viral replication in AIDS, may provide therapeutic benefit to those suffering from this disease.
Full browser ?