interleukin-12


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interleukin-12

[‚in·tər¦lük·ən ′twelv]
(immunology)
A heterodimeric cytokine that stimulates nonspecific cytotoxic natural killer-type cells to produce gamma interferon. Abbreviated IL-12.
References in periodicals archive ?
Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.
The company's lead product candidate is HemaMax[TM] (recombinant human interleukin-12, or rHuIL-12), which functions by targeting multiple pathways of hematopoiesis and innate immunity.
The pro-inflammatory functions of interleukin-12, as well as its ability to stimulate innate resistance and to generate a Th1-type immune response, are essential for resistance to different types of infection.
For example, wheat germ agglutinin can induce the secretion of cytokines such as interleukin-12 (IL-12), tumor necrosis factor (TNF)-[alpha], and interferon-[gamma] (IFN-[gamma]) in murine peritoneal macrophages (Sodhi and Kesherwani, 2007).
Other trials will couple the vaccine with additional immune system stimulants, such as interleukin-12, that may make the vaccine more powerful.
Kim, "Targeting Cytokines of the Interleukin-12 Family in Autoimmunity," Curr.
The patents in the new case are for human antibodies that bind a substance called interleukin-12, or IL-12, that regulates the immune system.
Merck Patent GmbH (Darmstadt, Germany) has patented methods for producing fusion proteins with the heterodimeric cytokine, interleukin-12.
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12.
Researchers found that the levels of interleukin-12 doubled and significantly increased T-cell counts (T-lymphocytes).
Vitamin D also promotes expression of regulatory T cells, suppresses interleukin-12, and balances Thl and Th2 T-cell responses.
The study revealed after 12 weeks, levels of interleukin-12, which boosts the immune response, doubled.