interleukin-12


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interleukin-12

[‚in·tər¦lük·ən ′twelv]
(immunology)
A heterodimeric cytokine that stimulates nonspecific cytotoxic natural killer-type cells to produce gamma interferon. Abbreviated IL-12.
References in periodicals archive ?
Complete primary structure, chromosomal localization and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit.
Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection.
Interleukin-12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance.
Albuterol sulfate-commonly used to treat bronchospasm, a constriction of the airways within the lungs as often occurs in asthma-may decrease interleukin-12 levels, the authors note.
Abbott scientists reported in the November 2007 issue of Nature Biotechnology, a scientific journal, that they created antibodies that latched onto Interleukin-12 and Interleukin-18, two components of the immune system.
Several investigators now propose that one of the body's initial responses to infection, the production of a compound called interleukin-12, may also awaken self-reactive immune cells.
European Cancer Congress 2015 Shailender Bhatia, MD, from the University of Washington School of Medicine and principal investigator for OncoSec's Phase II Merkel cell carcinoma trial, will present final results from this study in an oral presentation entitled: "Intratumoral Delivery of Interleukin-12 DNA via In Vivo Electroporation Leads to Regression of Injected and Non-injected Tumors in Merkel Cell Carcinoma: Final Results of a Phase II Study" at the European Cancer Congress on September 27 at 6:15 PM CEST at the Messe Wien Exhibition & Congress Centre in Vienna, Austria.
Ustekinumab is a human monoclonal antibody with a novel mechanism of action that targets the p40 sub-unit of two cytokines, interleukin-12 (IL-12) and interleukin-23 (IL-23) naturally occurring proteins that are important in regulating immune responses and that are thought to be associated with immune-mediated inflammatory disorders, including plaque psoriasis.
Writing about their work, the researchers have revealed that their tests have already involved interleukin-12, a drug currently in anti-cancer clinical trials.
Influence of Yersinia pseudotuberculosis outer proteins (Yops) on interleukin-12, tumor necrosis factor alpha and nitric oxide production by peritoneal macrophages.
Malaria investigators have been intrigued by the cytokine interleukin-12 (IL-12) because studies have shown that injections of IL-12 temporarily protect mice against infection by sporozoites.
The dominance of the tumor necrosis factor-alpha (TNF-a) inhibitors, primarily Amgen/Pfizer/Stiefel/Takeda's Enbrel and Abbott/Eisai's Humira, is being challenged by the interleukin-12 and 23 (IL-12/23) inhibitor Stelara (Janssen Biotech/Janssen-Cilag).