Eosinophils and CCR3 regulate interleukin-13
transgene-induced pulmonary remodeling.
Lipoxin A4 also discouraged type 2 innate lymphoid cells from promoting inflammation by blocking interleukin-13
levels in serum from patients with Hodgkin disease and healthy volunteers.
IL-13R alpha2 is believed to be a naturally occurring decoy receptor, capable of binding the cytokine Interleukin-13
(IL-13), but not transmitting a signal to the inside of the cell.
The present Brief Report about biologics such as antibodies, proteins, peptides, antisense and small interference RNA (siRNA) targeting the cytokine interleukin-13
or its receptors IL-13R alpha and IL-4Ralpha provides a competitor analysis of these anti-inflammatory molecules.
Analysis of data from the study found that a clinically-relevant reduction in AAER occurred in a sub-population of patients that had an elevated biomarker associated with increased interleukin-13
Washington, Mar 23 (ANI): A study conducted by researchers at Duke University has found that changes that occur in the airways of asthma patients are in part caused by the naturally occurring protein interleukin-13
(IL-13) which stimulates invasion of airway cells called fibroblasts.
Dupilumab's "powerful ability" to block interleukin-4 and interleukin-13
pathways of inflammation is "especially exciting because AD is even more Th-2-cell driven in children," said Michael J.
Elevated levels of TH-2 cytokines such as inter-leukin-5 and interleukin-13
are also present.
VIENNA -- The success of the interleukin-13
blocker lebrikizumab in the TREBLE trial provides a new avenue in the treatment of moderate to severe atopic dermatitis.
This patent includes specific variations in the inflammatory gene for interleukin-13
(IL-13) and represents part of our expanding coverage of inflammation genes outside the IL-1 gene cluster," added Kenneth S.