intermediate filament


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intermediate filament

[‚int·ər′mēd·ē·ət ′fil·ə·mənt]
(cell and molecular biology)
Any of several classes of cell-specific cytoplasmic filaments of 8-12 nanometers in diameter; protein composition varies from one cell type to another.
References in periodicals archive ?
Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments.
The tumors from patient 1 (Figure 3, A and B) and patient 2 (Figure 3, C and D) were composed of bipolar spindle cells with occasional intermediate filaments, no definitive secretory granules, and no significant accumulation of mitochondria.
Special studies have found that amyloid in localized cutaneous amyloidosis contains keratin epitopes, which suggests derivation of the fibrillar component from keratin intermediate filaments (6) (Table).
Immunopathology Antibodies * Breast Cancer Markers * Cell Cycle Antigens * Cellular & Oncofetal Antigens * Endocrine Antigens * Enzyme Antigens * Hemapoietic Markers * Immunoglobulins * Infectious Agents * Intermediate Filaments * Melanoma Panels * Multidrug Resistance Markers * Nephology/Urology Panels * Prognostic Markers * Tumor-Associated Markers Neuropathology Antibodies * Amyotrophic Lateral Sclerosis (ALS) * Alzheimer's Disease * Amyloidosis * Diffuse Axonal Injury * Huntington's Disease * Parkinson's Disease * Prion Diseases * Schizophrenia Detection
The cells displayed numerous desmosomal connections, complex interactions of the lateral membranes, and abundant intermediate filaments within the cytoplasm.
The pathophysiology of vascular damage in maternal decidual vasculopathy is unknown, but the 2 key findings in the involved vessels in this lesion are well described: (1) atherosis appears to be histiocytic phagocytosis of damaged endothelial cells of the spiral arteries, and (2) the dense pink fibrinoid necrosis may be some amalgam of the coagulation cascade proteins and intermediate filaments.
The Role of Keratin FRSE, FMedSci Intermediate Filaments in The University of Dundee, Tissue School of Life Sciences - Kenneth W.
The exact percentage of glassy cells needed to make the diagnosis of GCC is not well established, but it may range from 30% to 100%[1,9] Ultrastructurally, glassy cells may show intermediate filaments, polyribosomes, tonofibrils, and desmosomes.
Ultrastructural examination revealed paranuclear aggregates of intermediate filaments and poorly formed cell junctions.

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