intermediate filament


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

intermediate filament

[‚int·ər′mēd·ē·ət ′fil·ə·mənt]
(cell and molecular biology)
Any of several classes of cell-specific cytoplasmic filaments of 8-12 nanometers in diameter; protein composition varies from one cell type to another.
References in periodicals archive ?
Axotomy-induced changes in the expression of a type III neuronal intermediate filament gene.
Figure 12: infectious muscle 1 hour after injection, Desmin intermediate filament (arrowhead) within the Myocytes that surrounding by inflammatory cells (arrow) is seen.
As such, dystrophin constitutes a major scaffolding protein of normal muscle which links cytoskeletal actin, microtubules and intermediate filaments to the extracellular matrix.
These obsevations suggested that intermediate filaments may play a role in the intracellular transport of GSLs.
The [alpha]-helical rod domain is critical for the assembly of intermediate filament proteins into filaments and contains all the information necessary for assembly, while the variant end domains play accessory roles in filament assembly and interaction with other proteins and cell structures.
REVIEW OF INTERMEDIATE FILAMENTS, WITH SPECIAL REFERENCE TO CYTOKERATINS.
Intermediate filaments (IFs) participate in key mechanical functions and play a role in preventing excess large cell stretch.
CNS stem cells express a new class of intermediate filament protein.
Deregulation of intermediate filament protein phosphorylation leads to pathogenesis: a review.
In peritoneal cells, bundles of intermediate filaments appear to be broken into short fragments (Fig.
In a prospective study of 59 randomly selected patients with chronic hepatitis C virus (HCV) infection, a high degree of inflammatory liver injury on liver biopsy was associated with greater levels of the products that result from the cleavage of cytokeratin-18 (CK-18, a major intermediate filament protein in liver cells) by caspases during apoptosis (Hepatology 2004;40:1078-87).
The active component in Keratec IFP is a soluble form of intermediate filament protein made up primarily of a fibrous protein derived from New Zealand wool.

Full browser ?