Tissue Fluid

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Tissue Fluid

 

(also called interstitial fluid), the fluid in the intercellular and pericellular areas of tissues and organs in animals and man. Tissue fluid bathes all tissue elements and, together with the blood and lymph, constitutes the body’s internal medium. The cells absorb necessary nutrients from the tissue fluid and discharge metabolic products into it.

The chemical composition and the physical and biological properties of tissue fluid differ in the various organs and correspond to the organs’ morphological and functional characteristics. Tissue fluid is similar to blood plasma, but contains less protein (about 1.5 g per 100 ml) and different proportions of electrolytes, enzymes, and metabolites. The composition and properties of tissue fluid have a specific homeostasis, which protects organ and tissue cells from the effects of changes in blood composition.

Nutrients essential for the tissues enter the tissue fluid from the blood, and metabolites are removed from the tissue fluid through the histohematic connective tissue barrier. When the tissue fluid flows from the organs into the lymphatics, it becomes lymph. The volume of tissue fluid in a rabbit amounts to 23–25 percent of the body mass; in man it amounts to 23–29 percent, with an average of 26.5 percent. Many histologists regard as tissue fluids the cerebrospinal fluid, the pericardial fluid, the fluid of the anterior chamber of the eye, and the fluid of the pleural cavity.

References in periodicals archive ?
The low abundance of these peptides in interstitial fluid is likely due to their continuous release from the tumor microenvironment to accumulate in the blood.
Interstitial fluid pressurization seems to be a primary mechanism in the regulation of the frictional response of articular cartilage.
Bantle J, Thomas W: Glucose monitoring using dermal interstitial fluid.
The drift during constant pressure application was likely because of the viscoelastic nature of the soft tissues and the slow movement of interstitial fluid out of the limb.
Direct access to interstitial fluid in adipose tissue in humans by use of open-flow microperfusion.
Indicated for people ages 18 and older, the FreeStyle Navigator System is designed to continually record interstitial fluid glucose levels for the purpose of improving diabetes management.
The goal of Phase II, which is expected to be completed in mid-2010, is to optimize the sensing system for its glucose response in the presence of blood and interstitial fluid matrix components and demonstrate the integration of the components into a stable and reproducible glucose sensor.
NI methods attempt to determine glucose in other body fluids, such as in tissue interstitial fluid, eye vitreous fluid, or tears, as substitutes for venous or capillary blood glucose.
As previously announced, the goal of Phase II is to optimize the sensing system for its glucose response in the presence of blood and interstitial fluid matrix components and demonstrate the integration of the components into a stable and reproducible glucose sensor.
This sampling method involves penetration by a cannula into the dermis and allows for the routine collection of ~1 [micro]L of interstitial fluid (ISF), with a median collection time of between 4 and 5 s.
Phase II development, which includes optimizing the sensing system for its glucose response in the presence of blood and interstitial fluid matrix components, is expected to be completed in mid-2010.
A method for sampling interstitial fluid (ISF) from which glucose can be measured has been developed in our laboratory.

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