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ONCONASE treatment was associated with significant decrease in lactic acid in tumors as well as increased tumor blood flow, suggesting the acute effect of ONCONASE may, in part, be due to its ability to reduce tumor interstitial fluid pressure (TIFP). ONCONASE significantly lowered tumor interstitial fluid pressure (TIFP); increased tumor blood flow ( As part of these studies, the effect of ONCONASE on tumor interstitial fluid pressure (TIFP) was examined. |
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