interstitial nephritis


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interstitial nephritis

[¦in·tər¦stish·əl nə′frīd·əs]
(medicine)
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Pathophysiology of drug-induced nephropathy Level of the nephron Action Drugs Preglomerular Afferent arteriolar Cyclosporine (afferent arteriole) constriction Glomerulus Decreased GFR NSAIDs (prostaglandins) Gold, NSAIDs Glomerulonephritis Penicillamine, cisplatin Proximal tubules Acute tubular necrosis Aminoglycosides, radiocontrast dyes Distal tubules Renal tubular ACE inhibitors, acidosis type 4 cyclosporine Tubules and ducts Crystalluria Acyclovir, sulphonamide Interstitium Interstitial nephritis Penicillin, allopurinol Renal papilla Papillary necrosis NSAIDs, analgesics Table 2.
Interstitial nephritis has also been reported, and some of these patients recovered with corticosteroid therapy (Foley, Kapatkin, Verani, & Weinman, 1984).
Persistent leucocyturia could be associated with the tubercle bacillus, renal stones or interstitial nephritis.
An intense interstitial nephritis with severe calcification develops as the renal response to the now active infection.
The first series of autopsy reports to confirm renal disease in HIV-infected patients with clinically advanced disease showed a broad spectrum of lesions that include ATN, interstitial nephritis, nephrocalcinosis, minimal change, mesangial proliferation/hyperplasia and focal glomerulosclerosis (FGS).
1-3) Firstly, an acute interstitial nephritis (AIN) with associated proteinuria, hematuria, pyuria, urinary frequency and dysuria, is commonly seen in the acute phase of brucella infection and is caused by direct invasion of the bacterium.
Tubular necrosis, interstitial nephritis or thrombotic angiopathy are common causes of parenchymal drug-induced renal injury.
Although the most commonly noted renal pathologic finding is acute interstitial nephritis, acute tubular cell necrosis is also described.
When a prominent interstitial inflammatory infiltrate is present between well-preserved tubules with interstitial edema and tubulitis (lymphocytes present between the tubular basement membrane and tubular epithelial cells), this warrants the diagnostic consideration of acute interstitial nephritis.
The nephritis in brucellosis is usually classified as three types: acute interstitial nephritis or pyelonephritis during the course of acute infection, chronic involvement with granulomas and caseification necrosis, and renal involvement in association with Brucella endocarditis.
Cases of severe interstitial nephritis associated with rapidly progressive renal failure have been reported in countries other than Belgium.

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