4] Laminated intervillous thrombi (linear streaks of fibrin with degenerating red and white blood cells in between) are thought to be caused by leakage of fetal blood into the intervillous spaces
via defects in the trophoblast, usually occurring at varying times and leading to clotting of mixed fetal-maternal blood as a mechanism to limit fetal blood loss and fetomaternal bleeding.
The absence of 2 stage of spiral arterial invasion causes dysfunctional perfusion of intervillous spaces
with oxidative and hemodynamic stress.
Accumulation of infected erythrocytes in placental intervillous spaces
characterizes malaria during pregnancy (3).
27) suggest that TM plays an important role in preserving the role of stromal myofibroblasts in villous contractility and modulation of the intervillous spaces
affecting both foetal and maternal circulation (28, 29).
Maternal blood enters the intervillous spaces
through the spiral arterioles and bathes the chorionic villi.
The pathogenesis of PE, although poorly understood, has been associated with apoptotic change of the villous trophoblasts (11), possibly secondary to inadequate oxygenation of blood within the intervillous spaces