This differential diagnosis is specially considered when, in an adult, a tumor is localized in the lower extremities; it is dermal based without an intraepidermal
component, the patient has no previous history of malignant melanoma, and the tumor expresses S-100 protein.
Early diabetic neuropa Thermal thresholds and intraepidermal
nerve fibre density in patients with normal nerve conduction studies.
pagetoid spread is common in SC and is absent in BCC.
It has been demonstrated that intraepidermal
CD8+T cells with an effector-memory phenotype residing in FDE lesions have a major contributing role in the genesis of localized tissue damage.
In some cases, for example, a patient who has hidroacanthoma simplex (HAS; also known as intraepidermal
eccrine poroma) may be misdiagnosed as SK.
Examination of the biopsy specimen obtained from the knee revealed regular acanthosis and hypogranulosis, mild spongiosis, and intraepidermal
clusters of neutrophils (Munro's microabscess) in the epidermis, and the diagnosis of psoriasis was confirmed.
Histopathological examination showed intraepidermal
split with ballooning degeneration of epidermis with lymphocytic inflammatory infiltrate in the dermis.
This reversal of cisplatin-induced neuropathy by HDAC6 inhibition was associated with a restoration of intraepidermal
nerve fiber density, which is reduced by cisplatin treatment, indicating that HDAC6 inhibition results in re-growth of nerves into the skin.
1] Pemphigus is caused by autoantibody (IgG) deposition against Desmoglein (1 and 3) antigens located in the desmosomes of epidermal keratinocytes or 9[alpha] nicotinic acetylcholine receptors, leading to acantholysis and intraepidermal
4 Recent classification depends on the level of tissue cleavage following trauma5, there are three major subtypes; EB simplex where cleavage is intraepidermal
, it appears at birth with bullae formation limited to hands and feet that heal without scaring6, dystrophic EB where splitting is at sub lamina densa with bullae formation on feet, ankles, elbows and hands with absent or dystrophic nails and oral lesions that healed with scars, junctional EB the cleavage at lamina lucida , lesions appear at birth bullae and erosions formed which healed with scars on hands and feet with dystrophic nails and oral lesions.
This study demonstrated that intraepidermal
nerve fibers were already significantly reduced in 20% of patients within a year of their diabetes diagnosis.
The skin biopsy showed a predominance of folliculotropism (Figure 2c), compared to a less-remarkable epidermotropism, with intraepidermal
clusters of atypical lymphocytes larger than benign recruited dermal lymphocytes, as well as perinuclear vacuolization seen in the patch- and plaque-stage of MF (H&E stain, 2a, b.