Rescreening in gynecologic cytology: rescreening of 3762 previous cases for current high-grade squamous intraepithelial
lesions and carcinoma--a College of American Pathologists Q-Probes study of 312 institutions.
ATLANTA -- High-grade anogenital intraepithelial
neoplasia has remarkably high recurrence and malignancy potential despite repeated treatments; thus long-term surveillance is mandatory, according to Dr.
However, many were also using HPV testing for patients with Pap test results showing higher-grade lesions; 84% said they used it for atypical squamous cells results (cannot exclude high-grade squamous intraepithelial
lesions); 61% said they used it for low-grade squamous intraepithelial
lesions results; and 46% said they used it for high-grade squamous intraepithelial
lesions results, Dr.
A study of over 100 women with cervical intraepithelial
neoplasia (CIN, a precursor of cervical cancer) and their male sexual partners indicates that consistent condom use can speed up regression of HPV-associated lesions and infection.
More than a third of these women develop cervical dysplasia, also known as Cervical Intraepithelial
Neoplasia (CIN), a condition caused by the sexually transmitted Human Papilloma Virus (HPV).
Formalin-fixed, paraffin-embedded tissues included 56 anorectal biopsy or surgical resection specimens with the following tissue diagnoses: 29 low-grade squamous intraepithelial
lesion (encompasses condyloma, mild dysplasia, and anal intraepithelial
lesion 1), 15 high-grade squamous intraepithelial
lesion (encompasses moderate dysplasia, anal intraepithelial
lesion 2, severe dysplasia, anal intraepithelial
lesion 3, and carcinoma in situ), and 12 invasive squamous cell carcinoma.
The FUTURE II study was a combined analysis of data from three randomized, placebo-controlled trials that studied the impact of the vaccine on rates of HPV 16- and 18-related vulvar and vaginal intraepithelial
neoplasia grade 2/3.
This new method can accurately detect both intraepithelial
neoplasms and colitis-associated colorectal carcinomas, according to the study's principal investigator, Ralf Kiesslich, M.
HIV-1 infection and risk of vulvovaginal and perianal condylomata acuminata and intraepithelial
neoplasia: a prospective cohort study.
GTx is developing ACAPODENE[R] (toremifene citrate), a selective estrogen receptor modulator, or SERM, in two separate clinical programs in men: first, a pivotal Phase III clinical trial for the treatment of serious side effects of androgen deprivation therapy for advanced prostate cancer, and second, a pivotal Phase III clinical trial for the prevention of prostate cancer in high risk men with high grade prostatic intraepithelial
neoplasia, or PIN.
At our institution, most high-grade squamous intraepithelial
lesions (HSILs) corresponding to cervical intraepithelial
neoplasia (CIN) II and III are treated by loop electrosurgical excision procedure (LEEP).
LAS VEGAS -- Experts are divided on how aggressively cervical intraepithelial
neoplasia grade 2 should be treated, and on whether observation is an acceptable option, especially in low-risk populations.