The most common and the best defined in the literature precursor lesion leading to pancreatic ductal adenocarcinoma is pancreatic intraepithelial
For many decades it was assumed that HGSCs arise from the ovarian surface epithelium, but in 2001 this line of thinking was challenged by the identification of presumptive HGSC precursors--that is, serous tubal intraepithelial
carcinomas (STICs), and occult HGSCs in the fallopian tubes of patients with germline BRCA1 mutations who were undergoing prophylactic surgery.
USPRwire, Tue Aug 22 2017] This report provides comprehensive information on the therapeutic development for Cervical Intraepithelial
Neoplasia (CIN), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
The incidence of cervical cancer and cervical intraepithelial
neoplasia was found to be low relative to the high frequency of HPV infection showing that not all the HPV infected women develop cervical lesion, and not all the pre-neoplastic lesion get converted into invasive cervical cancer.
The likelihood of regression of mild dysplasia, called cervical intraepithelial
neoplasia grade 1 (CIN 1), is 60%.
Global Markets Direct's, 'Cervical Intraepithelial
Neoplasia (CIN) - Pipeline Review, H1 2016', provides an overview of the Cervical Intraepithelial
Neoplasia (CIN) pipeline landscape.
Anal and cervical cancers have many similarities that include association with human papillomavirus (HPV) infection, occurrence in an epithelial transformation zone, and coexistence with high-grade squamous intraepithelial
Neoplasia] and easy accessibility of the cervix to colposcopy and biopsy.
Abnormal cytologies included were atypical sqamous cells of undetermined significance (ASCUS), low-grade intraepithelial
lesions (LSILs), high-grade intraepithelial
lesions (HSILs) and invasive carcinoma.
The topics include colposcopy, negative for intraepithelial
lesion and malignancy, low-grade and high-grade squamous intraepithelial
lesions, atypical squamous cells of uncertain significance, adenocarcinoma, and cervical cancer screening and follow-up of limited and abnormal screen results.
The 3%-5% of all tested cases are classified as ASCUS (Atypical Squamous Cells of Undetermined Significance) and another 3%-5% are reported as low-grade squamous intraepithelial
lesion (LSIL), high-grade squamous intraepithelial
lesion (HSIL) or cervical intraepithelial
Ninety-seven men with high-grade prostatic intraepithelial
neoplasia and/or atypical small acinar proliferation were given capsules containing green tea catechins or a placebo for one year.