intragenic


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intragenic

[¦in·trə¦jen·ik]
(cell and molecular biology)
Within a gene, in referring to certain events.
References in periodicals archive ?
The remaining mutations consist of intragenic deletions/ duplications (approximately 2%) and microdeletions that span NF1 and neighboring genes (approximately 5%) (1).
All of these facts led us to conclude that intragenic recombination events enhanced allelic diversity.
An intragenic recombination event in a heteroallelic combination may give rise to a new allele with a significantly different phenotypic effect.
51] In addition, 3 mutations, one 9-bp intragenic deletion ([K.
In these cases, the Motor Chip was able to define breakpoint boundaries more precisely than previously used methods because of more accurate coverage of DMD intragenic regions (Table 2).
The genetic alterations in SSR regions include both point mutations and intragenic recombination that arise by slipped-strand mispairing during chromosomal replication and that result in a high degree of polymorphism (17,18).
Horne BD, Camp NJ Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation.
Intragenic recombination and a chimeric outer membrane protein in the relapsing fever agent Borrelia hermsii.
Submicroscopic deletions have also been detected in 6% to 17% of FAP families (6) by Southern blot analysis, apparent nonparental segregation of intragenic or flanking polymorphic marker alleles, fluorescence in situ hybridization (FISH) analysis, quantitative real-time PCR (QRT-PCR), comparative genomic hybridization, RNA analysis, and multiplex ligation-dependent probe amplification (MLPA) (6-11).
Large intragenic exonic deletions and duplications have been shown to be a frequent cause of many diseases.
The most common mutations are large intragenic deletions or duplications that encompass one or more exons (7).
In some populations, large intragenic BRCA1/2 deletions represent an important fraction of the mutation spectrum due to founder effects.