intrinsic factor


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intrinsic factor

[in′trin·sik ¦fak·tər]
(biochemistry)
A substance, produced by the stomach, which combines with the extrinsic factor (vitamin B12) in food to yield an antianemic principle; lack of the intrinsic factor is believed to be a cause of pernicious anemia. Also known as Castle's intrinsic factor.
References in periodicals archive ?
We consider that the increased values of B12 vitamin were due to a high titer of intrinsic factor antibody.
PA is macrocytic anemia due to vitamin B12 deficiency as a result of deficiency of intrinsic factor because of the atrophy of gastric mucosa and thus the loss of parietal cells.
Older patients have poorer stomach acid production and are frequently prescribed proton pump inhibitors, which stop the stomach from secreting hydrochloric acid intrinsic factor.
The free vitamin then binds with a glycoprotein, intrinsic factor (IF), originating from the gastric parietal cells.
Vitamin B12 binds with intrinsic factor before it is absorbed and used by your body (7,14,15).
The intrinsic factor indicated to what extent coaching is engaged in due to fun or enjoyment motives.
It is due to the malabsorption of Vitamin B12 resulting from lack of special factor called Intrinsic Factor, which the body needs to absorb the vitamin from food.
It is presented as an intrinsic factor in the model.
It is then bound by intrinsic factor and transported from the proximal ileum to the distal ileum, where it is then bound to transcobalamin II for transport to the liver and bone marrow.
Cobalamin is then transferred to intrinsic factor by means of pancreatic enzymes.
Medical dictionaries define pernicious anemia as "a severe anemia caused by the failure of the gastric mucosa to secrete the intrinsic factor necessary for the absorption of vitamin [B.
Pernicious anemia has its own definition: "A severe anemia caused by the diminution or absence of stomach acid secretion, with consequent failure of the gastric mucosa to secrete the intrinsic factor necessary for the absorption of vitamin [B.

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