It is the general consensus among microbiology and infectious disease specialists that molecular detection technology, whether protein-based assays such as electrospray mass spectrometry (ESI-MS), MALDI-TOF (matrix assisted laser desorption ionization time
of flight), or DNA-based technologies, is the future of microbiology.
Early this year, we began to evaluate a technology called Matrix Assisted Laser Desorption Ionization Time
of Flight Mass Spectrometry (MALDI-TOF MS), which holds the potential to help bypass some of the most time-consuming chores involved in pathogen culturing: identification and susceptibility testing.
A miniaturized matrix-assisted laser desorption/ ionization time
of flight mass spectrometer with mass-correlated acceleration focusing.
The AGC calculates the allowed ionization time
to produce the Target number for each scan from the number of ions collected during a fixed 100us ionization time