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Localized tissue anemia as a result of obstruction of the blood supply or to vasoconstriction.



a local deficiency of blood; insufficient blood in an organ or tissue because of the narrowing or complete occlusion of the lumen of an afferent artery.

Transitory ischemia (like hyperemia) may result from physiological regulation of the blood supply, such as in reflex spasm of an artery caused by a mental factor (fright); the influence of pain, cold, chemical substances (epinephrine, ergotin), and biological stimuli (bacteria, toxins); the obstruction of an artery by a thrombus or embolus; constriction of the lumen of a blood vessel in connection with an atherosclerotic or inflammatory process in the wall; or compression of an artery by a tumor, scar, or foreign body. The aftereffects of ischemia depend on the degree of disruption of the blood flow, the rate of development and duration of the ischemia, the sensitivity of the tissue to oxygen deficiency, and the general condition of the body. Ischemia may end in complete restoration of the structure and function of the affected organ or tissue, but it also may lead to necrosis (infarct). The central nervous system and heart muscle are particularly sensitive to ischemia.


References in periodicals archive ?
Healios and Nikon have entered into a business and capital alliance agreement for the commercialization of regenerative medicine products, and Healios is currently conducting the clinical trial in Japan to verify the safety and the efficacy of MultiStem for acute ischemic stroke.
Approximately 80% strokes are due to ischemic cerebral infarction and 20% are due to brain hemorrhage.
Conclusion: Ischemic postconditioning lowered the expressions of PTX3 and neutrophil CD11b in AMI patients after PCI, inhibited inflammatory response, reduced the adhesion between leukocytes and endothelial cells, and protected the ischemic-reperfused myocardium.
A follow-up MRI was performed three hours later in order to ascertain the ischemic pathogenesis of the clinical symptoms.
The promoter SNPs in CRP gene, CRP −717A > G and −286C > T > A gene polymorphisms, were proposed as possible biomarkers and suggested to be used to predict ischemic stroke in some researches.
The report reviews key players involved in the therapeutics development for Ischemic Stroke and enlists all their major and minor projects
Patients whose clinical and radiological findings were not consistent with acute ischemic stroke.
Women with PMVA who smoked had a greater risk of ischemic stroke (OR=1.
Coverage of the Ischemic Cerebral Stroke pipeline on the basis of route of administration and molecule type.
Devise corrective measures for pipeline projects by understanding Ischemic Cardiomyopathy pipeline depth and focus of Indication therapeutics.
In this study, the same stem cells were transplanted into the brains of pigs that received an ischemic stroke on one side of the brain.
Approximately 2-4 children per 10,000 births experience ischemic stroke in the first 28 days of life.