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isochromosome

   Also found in: Medical, Wikipedia 0.01 sec.
isochromosome [¦ī·sō′krō·mə‚sōm]
(cell and molecular biology)
An abnormal chromosome with a medial centromere and identical arms formed as a result of transverse, rather than longitudinal, splitting of the centromere.


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A high incidence of isochromosome 12p in leukaemic blasts has been reported and this is a genetic abnormality found in EGCT and gonadal GCT [23].
Thirty-eight (67%) of the cases with chromosomal abnormalities were karyotype 45,X; the rest of the observed chromosomal abnormalities were 45,X/47,XXX (n = 1), trisomy 21 (n = 7), trisomy 18 (n = 5), trisomy 13 (n = 2), triploidy (n = 1), tetraploidy (n = 1), isochromosome 22 (n = 1), and addition chromosome 4 (n = 1).
 
 
 
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