isochromosome


Also found in: Dictionary, Medical, Wikipedia.

isochromosome

[¦ī·sō′krō·mə‚sōm]
(cell and molecular biology)
An abnormal chromosome with a medial centromere and identical arms formed as a result of transverse, rather than longitudinal, splitting of the centromere.
References in periodicals archive ?
8) The study revealed that subjects with isochromosome karyotype had the smallest dental crown widths when compared to the other groups.
Females with an isochromosome of the long arms of the X chromosome have larger and more frequent drumsticks, whereas females with deletions from the X chromosome have smaller drumsticks (1), (15).
All cases were also negative for isochromosome 17q by fluorescent in situ hybridization.
double Ph, isochromosome 17q, trisomy 8 FISH analysis optional: * Only done where conventional cytogenetics not available or fails * Or, to document a BCR-ABL positivity for variant translocation and masked Ph Note: If BM material unavailable (e.
A high incidence of isochromosome 12p in leukaemic blasts has been reported and this is a genetic abnormality found in EGCT and gonadal GCT [23].
In addition, seven of the 20 cells contained an additional isochromosome 8q resulting in an 8q tetrasomy.
Thirty-eight (67%) of the cases with chromosomal abnormalities were karyotype 45,X; the rest of the observed chromosomal abnormalities were 45,X/47,XXX (n = 1), trisomy 21 (n = 7), trisomy 18 (n = 5), trisomy 13 (n = 2), triploidy (n = 1), tetraploidy (n = 1), isochromosome 22 (n = 1), and addition chromosome 4 (n = 1).
These include an increase in modal chromosome numbers to between 47 and 50, acquisition of a second Philadelphia chromosome (Ph), and an isochromosome for the long arm of chromosome 17 [i(17q)], -8(trisomy 8), -19, and t(15;17).
This process produces an isochromosome, but where the mutation succeeds, telomere sequences are added to the ends.
Isochromosome 12p by cytogenetic studies can be confirmatory in difficult cases.