isoschizomer


Also found in: Medical, Wikipedia.

isoschizomer

[‚ī·sə′siz·ə·mər]
(biochemistry)
One of two or more restriction endonucleases that cleave a deoxyribonucleic acid molecule at the same site.
References in periodicals archive ?
We used two different methods (Methods I and II) based on DNA digestion by HpaII (a methylation-sensitive enzyme) and MspI (a methylation-insensitive isoschizomer enzyme) followed by real-time PCR amplification to quantify methylation.
In theory, we might have repeated the experiments with a non-methylation-sensitive isoschizomer of the restriction enzyme; however, no such enzyme is available.
Digestion with the Cfr9I, an isoschizomer of SmaI, yielded identical PFGE profiles (Figure).
To interpret the H3 motif, primers CV140F and CV120R were designed to introduce a FokI site (an isoschizomer of BstF5I) in the amplified product by substituting the restriction recognition sequence GGATG for T (nucleotide -147) and G (nucleotide -110), respectively.