isosteric


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isosteric

[¦ī·sə¦ster·ik]
(chemistry)
Referring to similar electronic arrangements in chemical compounds.
(physics)
Of equal or constant specific volume with respect to either time or space.
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Their use of N-H pyrazoles for making charged tris(pyrazolyl)borate ligands (Tp), the neutral and isosteric analogues, tris(pyrazolyl)methane (Tpm) and tris(pyrazolyl)silane (Tps will be presented.
The main difference between these two compounds and other isosteric molecules is, for example, the rotational freedom of the aliphatic chain in chlorpromazine vs the fixed configuration of chlorprothixen.
The mission of Focus Synthesis is to provide tool sets for discovering the drugs of the future by optimizing diversity and enabling comprehensive single-site and isosteric changes in biologically active small molecules that result in optimal SAR knowledge.
These compounds have the potential for the preparation of charged tris(pyrazolyi)borate ligand (Tp), the neutral and isosteric analogues, tris(pyrazolyl)methane (Tpm)and tris(pyrazolyl)silane (Tps),which are useful in the design of new metal complexes with varied properties and reactivities.
Synthesis of a homovanillic acid immunogen that incorporates an isosteric group designed to generate antibodies with improved specificity.