Keloid


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keloid

[′kē‚lȯid]
(medicine)
A firm, elevated fibrous formation of tissue at the site of a scar.

Keloid

 

a tumor-like growth of the fibrous connective tissue of the skin.

The causes of keloid development are not clear. Certain persons have a predisposition to their development. A distinction is made between true (spontaneous) keloids, which develop on visibly unchanged skin, and false keloids, which develop at the site of a scar after trauma (mechanical, thermal, chemical) or purulent disease (a furuncle, for example). A true keloid is a slightly elevated formation (5–8 mm above the skin surface) of whitish or pinkish color and dense consistency, with a smooth, shiny surface. Keloids appear most often in young people in the area of the chest, neck, and pinnae; and more rarely, on the face and limbs. Growth takes place for several weeks or sometimes months, after which the dimensions of the keloid remain unchanged throughout the patient’s lifetime. Treatment consists of injections of hyaluronidase and vitreous body; administration of vitamins PP, B2, and C; electrophoresis of potassium iodide; paraffin therapy; and X-ray therapy.

References in periodicals archive ?
The American Academy of Dermatology website defines keloids as "raised overgrowths of scar tissue that occur at the site of a skin injury.
Transforming Growth Factor Beta 1 is produced in great quantities in keloids, and keloid fibroblasts respond to lower quantities of Transforming Growth Factor Beta 1 than normal fibroblasts.
Consecutive cases with keloid were included by the author irrespective of the aetiology.
sup][16] It turned out to be a predictable keloid behaving manner which demonstrated a 60% (18/30) regrowth at controlling rate and a nonsignificant time-dose relationship at controlling symptoms.
Some promise in the treatment of keloid has been offered by 5-fluorouracil (5-FU), which is a potent inhibitor of thymidylate synthetase and interferes with pyrimidine metabolism, thus DNA synthesis is blocked.
The purpose of this study was to make an ideal rabbit ear keloid model.
Indeed, excision of keloid without an adjuvant treatment to minimise recurrence results in a failure rate of 45% to 100%.
We have known for years that there has been practitioner demand for an efficacious and safe prescription treatment to manage hypertrophic and keloid scarring," Quinnova chief executive officer Jeffrey Day says.
The main features differentiating keloid scars from hypertrophic scars are that keloid scars enlarge and extend beyond the original injury site, there is no spontaneous regression and following excision there is a high recurrence rate.
A 19-month-old male of African descent was referred to us with a keloid of the shaft of the penis.