Keratinization


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Keratinization

 

the accumulation of keratins—a type of protein—in cells of the epithelial tissue in vertebrates and humans. Keratinization mainly occurs within the surface layers of the skin—the epidermis and all its derivatives (scales, bill, plumage, wool, hooves, horns, hair, and nails).

In humans the keratinized cells in the surface layers of the skin are converted into squamules, which form the cornified layer of the epidermis. This layer is highly elastic and conducts heat poorly, thus protecting the underlying layers of the skin from such harmful factors as physical injury, desiccation, and bacterial infection. Keratinization is most evident on the palms and soles, less so at flexures. (For disorders in the keratinization process, seeHYPERKERATOSIS.)

References in periodicals archive ?
Surgical correction of entropion, trichiasis, marginal keratinization, and functional lid shortening.
Smokeless tobacco contains high concentrations of calcium, which promotes epithelial differentiation; perhaps the calcium levels in the oral cavity leads to the keratinization of normally nonkeratinized mucosa.
Moderately differentiated SCC contains distinct nuclear pleomorphism and mitotic activity, including abnormal mitoses; there is usually less keratinization, but is still readily identified as squamous in type7,10,19.
B: Section showing islands of squamous cell carcinoma with areas of keratinization forming keratin pearls (H&E x200).
The abrasive action of its claws is believed to result in epithelial hyperplasia and increased keratinization.
Less differentiated areas in the tumor showing less keratinization and more nuclear pleomorphism is shown in Fig.
The characteristic morphologic markers associated with the keratinization process were not altered either in appearance or in amounts.
If slit lamp examination reveals flattening of the plica and keratinization of the caruncle along with the sign shown in Image A, what is the MOST likely diagnosis?
The keratinization process (division of dead cells) that occurs within the horse's hooves is the same as that of our finger and toenail growth.
2) Vitamin A deficiency can result in keratinization of oral mucosa and the respiratory and gastrointestinal tracts.
practice multiple times over the previous 7 years for routine grooming, and abnormal keratinization of the rhinotheca had been observed during that period, progressively worsening over time.
Circumcision may reduce these injuries due to the significant keratinization that occurs following the procedure," they speculated.