khellin


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khellin

[′kel·ən]
(pharmacology)
C14H12O5 A synthetic compound that crystallizes from methanol solution, has a bitter taste, melts at 154-155°C, and is more soluble in water than in organic solvents; used in medicine as an antispasmodic, a coronary vasodilator, and a bronchodilator. Also spelled chellin; khelin. Also known as visammin.
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7] Novel systemic therapies like L-phenylalanine, Polypodium leucotomos, Khellin, Ginkgo biloba, vitamins B12, C, E, folic acid and zinc have also been found to be effective.
2 Khellin and visnagin were identified from Ammi visnaga fruit and were proved that all of them have calcium channel blocking mode of action.
Improved high-performance liquid chromatographic determination of khellin and visnagin in Ammi visnaga fruits and pharmaceutical formulations.
Therapy of heart disease with khellin, with special reference to the khellinstrophanthin.
It was the aim of our study to evaluate the effect of a Khella extract (KE) as well as the two major constituents khellin and visnagin on renal epithelial injury using LLC-PK1 and Madin-Darby-canine kidney (MDCK) cells.
Keywords: Ammi visnaga Nephrolithiasis Hyperoxaluria Calcium oxalate Khellin Visnagin
Khellin fototoksik deri eritemine neden oimaz ve psoralenin aksine DNA mutasyonlarini arttirmaz (53).
Conventional antiasthmatic compounds, such as sodium cromolyn and sodium cromoglycate, were developed from analogs of the naturally occurring furanochromone khellin (visammin), found in the Asian plant Ammi visnaga.
Bashar Mohammad Harb Hamad In recognition of a programme of work entitled, "Synthesis and Pharmacological Evaluation of Novel Khellin Analogues as Potential Cardioprotective Agents", carried out at Coventry University, under the direction and supervision of Dr T Javed, Senior Lecturer, School of Science and the Environment, Coventry University and Dr S O Fagbemi, Senior Lecturer, Department of Forensic and Biomedical Sciences, Faculty of Health Life and Social Sciences, University of Lincoln.
The regular daily administration of inhaled corticosteroids (beclomethasone, budesonide, and fluticasone) and/or khellin derivatives (cromoglycate and nedocromil) greatly assist in the control of asthma and EIA in athletes who are tempted to inhale larger quantities of salbutamol.
Its main agent, Khellin, is completely bioavailable already after 10 min, in favourable comparison to pure equimolar Khellin, which is not fully resorbed until 60 min (Eder and Mehnert 2000).