kinase


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kinase

[′kī‚nās]
(biochemistry)
Any enzyme that catalyzes phosphorylation reactions.
References in periodicals archive ?
The NanoBRET TE platform combines the sensitivity of NanoLuc technology with quantitative capabilities of energy transfer, and allows for quantitative measurements of drug affinity and kinase selectivity inside live cells at target levels similar to that of endogenous kinases.
150 top ranked compounds were selected on the basis of docking score for each PIM kinase to evaluate further.
The United States Food and Drug Administration's milestone approval in 2001 of the first kinase inhibitor, imatinib, was followed by a steady approval of kinase inhibitors over the next 10 years.
Kinase Inhibitors for Cancer Treatment Market: Drivers and Restraints
These data suggest a way in which receptor tyrosine kinase inhibitors could be used to treat individuals with KRAS mutant colorectal cancers.
CaM kinase adds phosphate groups to other proteins, a process known as phosphorylation.
p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle.
Future work will more precisely delineate the mechanism and test additional kinase inhibitors for their interventive potential.
We feel that the PLK1-B23 phosphorylation story nicely demonstrates the power of the Kinetworks(TM) approach to rapidly and cost-effectively discover protein kinase drug targets and the means to identify their inhibitors" said Dr.
And this raises the dazzling possibility that a class of drugs now in development--the p38 MAP kinase inhibitors--could play a role in the treatment of each of the diseases in this eclectic group, Dr.
Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors.
levels, protein kinase activation, and the functional consequences of these changes on the target macrophage.