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L-dopa

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l-dopa (ĕl-dō`pə), drug used to alleviate some of the symptoms of Parkinson's disease Parkinson's disease or Parkinsonism, degenerative brain disorder first described by the English surgeon James Parkinson in 1817. When there is no known cause, the disease usually appears after age 40 and is referred to as Parkinson's disease.
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, particularly trembling, rigidity, and slow movements; the drug is also called levodopa. Parkinson's disease results when the concentration of dopamine in the brain is depleted (see catecholamine catecholamine , any of several compounds occurring naturally in the body that serve as hormones or as neutrotransmitters in the sympathetic nervous system. The catecholamines include such compounds as epinephrine, or adrenaline, norepinephrine, and dopamine.
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). Medical administration of dopamine itself is ineffective since that chemical apparently does not enter the brain from the blood. A metabolic precursor of dopamine, l-dopa does enter the brain via the bloodstream and is probably converted into dopamine there. Because there are many brain disorders with similar symptoms, many patients do not show any improvement when treated with the drug. Furthermore, virtually all patients on l-dopa experience side effects including nausea, loss of appetite, cardiac irregularities, and psychological changes.

levodopa

 or L-dopa

Organic compound (L-3,4-dihydroxyphenylalanine) from which the body makes dopamine, a neurotransmitter deficient in persons with parkinsonism. When given orally in large daily doses, levodopa can lessen the effects of the disease. However, it becomes less effective over time and causes abnormal involuntary movements (dyskinesia).


L-dopa [¦el ′dō·pə]
(pharmacology)


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The research team, which included Dr Tamara Shiner and Professor Ray Dolan, examined estimated pleasure of future events before and after the administration of a drug called L-DOPA which is known to enhance dopamine function in the brain and is commonly used to treat patients with Parkinson's disease.
They were then given L-DOPA or a placebo and asked to imagine holidaying in those destinations.
Researchers are investigating if the drug L-dopa, alongside physiotherapy and occupational therapy, can boost stroke patients' mobility and increase their chances of walking again.
 
 
 
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