lapachol


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lapachol

[lə′pä‚chȯl]
(biochemistry)
C15H14O3 A yellow crystalline compound obtained from lapacho, a hardwood in Argentina and Paraguay. Also known as lapachoic acid; targusic acid.
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What does it do: The inner bark contains the effective chemical ingredients which are anthraquinones, coumarins, flavanoids, iridoids and napthaquinones and contain the extract lapachol that gives rise to the remarkable claims made for this plant.
Vargas, Molluscicidal Activity of Synthetic Lapachol Amino and Hydrogenated Derivatives, Bioorg.
alternata) from Aegiceras corniculatum and Tabebuia argentea which produce quinones alterporriol K and lapachol, respectively.
This naphthoquinone derivative is an analogue of [beta]-lapachone, a naphthoquinone derived from lapachol isolated from Tabebuia avellanedae (Bignoniaceae), and showed anti-proliferative activity against a number of cancer cell lines such as DLD-1 and HT-29 human colon carcinoma (Ashwell et al.
Scientific name (1) Notes Chemical constituents/Countries using love potions Bignoniaceae Lapachol in genus/Trinidad and Tabebuia bahamensis Jamaica (Northrop) Britt.
However, it is necessary to clearly identify compounds other than lapachol that have anti-infectious activity and the mechanisms of action responsible for these activities.
84) The active constituents in Pau d'arco are believed to be the naphthoquinone derivative, lapachol, and its derivatives (ie.
Constituyentes de los extractos de la corteza (naftoquinonas, el lapachol y la P-lapacona) han sido estudiados intensivamente dadas sus propiedades antiinflamatorias y anticancerigenos (89, 90).
Itokawa et al (1992) proved that the alcoholic extract of Mansoa alliacea shows cytotoxic activity against V-29 cells, due to the presence of lapachol, which exhibits potent antitumor activity.
Among the various bio-active constituents reported from Bignoniaceae family plantsand reviewed in the present study, some of the more common but pharmacologically important compounds are ursolic acid, oleanolic acid, a- and b-lapachone, lapachol, verbascoside, corymboside, lupeol, quercitrin, apigenin, pomolic acid, and isoacteoside.
Os extrativos de folhosas tambem contem fenois simples (sinapaldeido, acido piruvico, eugenol etc), lignanas (lioniresinol, acido tomasico etc) e quinonas (tetraquinona, lapachol, 4--metoxidalbeginona etc) (AREA, 1988).
Entre os componentes quimicos descobertos, encontram-se o lapachol e os flavonoides (quercentina, 2-vicenina e hespertina), diterpenos (casearinas A-S, clerodanos I-VI, casearvestrinas A-C), sesquiterpenos e acido caprionico (BORGES et al.