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lethal gene

   Also found in: Dictionary/thesaurus, Medical, Legal, Wikipedia, Hutchinson 0.02 sec.
lethal gene [′lē·thəl ′jēn]
(genetics)
A gene mutation that causes premature death in heterozygotes if dominant, and in homozygotes if recessive. Also known as lethal mutation.


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The discovery of a lethal gene in Holsteins may explain why pregnancy rates have dropped 20% in Holsteins over the last two decades.
In one fruit fly line, the team inserted a three-part genetic time bomb: a lethal gene that disrupts signaling in cells, a switch controlling it that flips only in females, and a control for that switch that keeps it in its off state when the fly consumes the antibiotic tetracycline.
 
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