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leucovorin

   Also found in: Medical, Acronyms, Wikipedia 0.03 sec.
leucovorin [lü′käv·ə·rən]
(pharmacology)
Folinic acid used as a calcium salt to counteract the toxic effects of folic acid antagonists and for treatment of megaloblastic anemias.


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The Food and Drug Administration (FDA) today announced the approval of Eloxatin (oxaliplatin) injection for use in combination with infusional 5-fluorouracil (5-FU) and leucovorin for the treatment of patients with colorectal cancer whose disease has recurred or become worse following initial therapy with a combination of irinotecan with bolus 5-FU and leucovorin.
Although drugs against the infection are already available, researchers have considered trimetrexate a less toxic or more effective alternative if used in conjunction with leucovorin.
AVASTIN([R]) and Leucovorin are also being administered in treating colorectal patients.
 
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