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leucovorin

   Also found in: Medical, Acronyms, Wikipedia 0.01 sec.
leucovorin [lü′käv·ə·rən]
(pharmacology)
Folinic acid used as a calcium salt to counteract the toxic effects of folic acid antagonists and for treatment of megaloblastic anemias.


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Standard first-line treatments including fluorouracil (5-FU) with leucovorin (LV) and irinotecan or oxaliplatin, alone or combined with bevacizumab, have resulted in a median overall survival (mOS) greater than 20 months [3-9].
Of the 348 tumor samples that expressed normal KRAS, one-year progression-free survival rates were 25% and 43% for patients with normal KRAS tumors receiving FOLFIRI (fluorouracil, leucovorin, and irinotecan) and the combination of cetuximab plus FOLFIRI, respectively.
Two major chemicals that most physicians prefer to apply for the best result in colon cancer are fluorouracil (5-FU) and leucovorin.
 
 
 
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