leukocidin


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leukocidin

[‚lü·kə′sīd·ən]
(biochemistry)
A toxic substance released by certain bacteria which destroys leukocytes.
References in periodicals archive ?
Genes encoding for Panton-Valentine leukocidin (PVL), LukS-PV, and LukF-PV were identified by the reference laboratory, as described (18).
Community-acquired MRSA tends to be susceptible to those agents, but it often has genes for Panton-Valentine leukocidin, the presumed virulence factor for its necrotizing ability.
4] These bacteria produce a lipopolysaccharide endotoxin with strong biologic activity, as well as a leukocidin and hemolysin, assisting in destruction of white and red blood cells.
PCR was used to screen for staphylococcal cassette chromosome mec type and to detect Panton-Valentine leukocidin genes for all isolates (22).
These CA-MRSA clones usually produce Panton-Valentine leukocidin (PVL), a pore-forming toxin encoded by 2 genes, lukF-PV and lukS-PV (4).
Detection of genes encoding Panton-Valentine leukocidin (PVL), toxic shock syndrome toxin (TSST), arginine catabolic mobile element (ACME), and high-level mupirocin resistance (mupA) was also performed.
None of the isolates harbored the genes coding for Panton-Valentine leukocidin.
Staphylococcal cassette chromosome mec (SCCmec) typing was performed (8), and the presence of Panton-Valentine leukocidin (PVL) genetic determinants was assessed as described (9).
Although the rapid dissemination of the USA300 clone may occur because of a high virulence level that arises from the production of Panton-Valentine leukocidin (PVL) or an existing arginine catabolic mobile element (ACME) (2), there is no conclusive evidence to support this hypothesis (3).
Genes encoding the following virulence factors were also evaluated by PCR, but none were detected: Panton-Valentine leukocidin, arginine catabolic mobile element, staphylococcal enterotoxins A-E, exfoliating toxins A and B, and toxic shock syndrome toxin 1.
MRSA isolates were tested for the genes encoding for Panton-Valentine leukocidin (PVL) by PCR (22).
aureus were characterized by pulsed-field gel electrophoresis (PFGE), mecA identification, staphylococcal cassette chromosome (SCC) mec typing, Panton-Valentine leukocidin identification, agr typing, MLST, and spa typing as described (1,6).