Our findings suggest that neutrophils play a key role in allergic skin inflammation and that blockade of leukotriene
B4 and its receptor might provide a new therapy for eczema," said first author Dr.
This minority of asthmatics likely represents the fraction of asthmatics that would improve significantly from anti-leukotriene
drugs, including a 5-lipoxygenase inhibitor or leukotriene
Effect of SC-41930, a potent leukotriene
B4 receptor antagonist, in the guinea pig model of middle ear inflammation.
Treating asthma: is there a place for leukotriene
First line medications used to treat exercise-induced asthma Proventyl/salbutamol 2 puffs 15 minutes prior to exercise Cromolyn sodium 2 puffs 20 minutes prior to exercise Salmeterol 2 puffs 30 minutes prior to exercise Good for latent phase EIA Leukotriene
inhibitors Taken by mouth at least 1 hour prior to exercise
But best of all would be the ability to avoid the substances in the air that produce leukotriene
formation in the first place.
a private biopharmaceutical company developing a new class of drugs to treat chronic inflammatory disorders, today announced the initiation of a first-in-human Phase 1 clinical study of CTX-4430, which blocks the pro-inflammatory enzyme Leukotriene
A4 Hydrolase (LTA4H).
INV104 (zafirlukast) is a leukotriene
receptor antagonist (LTRA) or anti- leukotriene
that reduces inflammation, constriction of the airways, and the build-up of mucus in the lungs.
The active ingredient in the drug, Montelukast is in a class of medications called leukotriene
In this study, Dutch researchers measured 15 substances in the blood 1 leukotriene
B(4) (LTB), LTC(4), LTC(4), LTE(4), prostaglandin D(2) (PGD ), PGE(2), PGF(2) (a), thromboxane B(2), lipoxin A(4), eosinophil cationic protein, eosinophil-derived neurotoxin/eosinophil protein X, eosinophilic peroxidase, myeloperoxidase, histamine and tryptase - and five substances in urine before and up to 72 hours after a bronchial allergen challenge.
On the other hand, women were significantly more adherent for leukotriene
gammaT, but not alphaT, significantly inhibited the formation of leukotriene
B4, a potent chemotactic agent synthesized by the 5-lipoxygenase of neutrophils.