leukotriene


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leukotriene

[‚lü·kō′trī‚ēn]
(biochemistry)
Any of a family of oxidized metabolites of certain polyunsaturated fatty acids, predominantly arachidonic acid, that mediate responses in allergic reactions and inflammations, produced in specific cells upon stimulation.
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Inhibitors of proliferation of mesangial cells, for example, leukotriene antagonists, may offer therapeutic options for the treatment of proliferative glomerular diseases [29].
It may also be effective for EC treatment due to its selective inhibition on leukotriene receptor mediated response.
His team also found that deleting the receptors on immune cells that bind to leukotriene B4 had a similar effect.
The leukotriene inhibitors (montelukast and zafirlukast) and 5-lipoxygenase inhibitor (zileuton) improve airway function primarily by blocking the inflammatory effects of various leukotrienes (fig.
A study found that tablet drugs called leukotriene receptor antagonists (LTRAs) alleviated mild asthma just as well as steroid inhalers.
The tablets, called leukotriene receptor antagonists, are currently recommended as third or fourth steps in asthma treatment because of the belief that they are less effective.
Pathophysiological role of mast cells in collagen-induced arthritis: Study with a cysteinyl leukotriene receptor antagonist, montelukast.
The goalposts have changed recently with the addition of long-acting beta 2 agents such as salmeterol and the recent advent of leukotriene modifiers.
We conducted a prospective, randomized, placebo-controlled, double-blind study to determine if the leukotriene inhibitor montelukast is effective in eliminating persistent middle ear drainage in patients with otitis media with effusion (OME).
Clinical trials in adults have shown that combining ICS with a long-acting beta-agonist such as salmeterol produces greater lung function improvements than combining the ICS with the leukotriene antagonist montelukast, Dr.