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Related to lewisite: British anti lewisite


(lo͞o`əsīt'), liquid chemical compound used as a poison gaspoison gas,
any of various gases sometimes used in warfare or riot control because of their poisonous or corrosive nature. These gases may be roughly grouped according to the portal of entry into the body and their physiological effects.
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. Like mustard gas and nitrogen mustard, it is a blistering agent; when inhaled, it is a powerful respiratory irritant. The absorption of lewisite, which penetrates ordinary clothing and even rubber, through the skin may be fatal. Chemically, lewisite is dichloro-2-chlorovinyl arsine, ClCHCHAsCl2. It boils with decomposition at 190°C;, and its vapor has a faint odor of geraniums. Lewisite is neutralized by reaction with British antilewisite (2, 3-dimercapto-1-propanol). It is named after its developer, the American chemist Winford Lee Lewis.



(after the American chemist W. L. Lewis, 1878-1943), ClCH=CHAsCl2, β-dichloro(2-chlorpvinyl) arsine (αlewisite), a war gas with a toxic (systemic), irritating, vesicant effect. The commercial product contains admixtures of bis (β-chlorovinyl) chloroarsine (ClCH = CH)2AsCl (βMewisite) and tris (β-chlorovinyl) arsine (ClCH=CH)3As (γ-lewisite).

A mixture of cis and trans isomers, a-lewisite is characterized by boiling points of 170° and 196°C (melting points, —44 and -1.2°C; density, 1.6092 g/cm3 at 23.5°C). All of these compounds are colorless liquids, insoluble in water but readily soluble in organic solvents.

In water, α-lewisite undergoes rapid hydrolysis to form toxic β-chlorovinylarsenic oxide C1CH—CHAsO. With oxidants (H2O2, HNO3), it is converted to β-chlorovinyl arsenic acid C1CH = CHAsO(OH)2. In the presence of alkalis, a-lewisite readily dissociates to yield acetylene, and c/s-α-lewisite dissociates to yield vinyl chloride.

Lewisite is formed by the reaction of acetylene and AsCl3 in the presence of AlCl3, HgCl2, and other catalysts.

The human body cannot tolerate lewisite concentrations greater than 2.10-2mg per l, which irritate the upper respiratory passages. The lethal doses are 0.25 mg/per l (15 min) when inhaled and 25 mg per kg when absorbed through the skin. Dimercaptopropanol and its derivatives are effective in the treatment of lewisite-induced affections.

Lewisite was first obtained at the end of World War I (1914-18), but it was never used for military purposes.


Rukovodstvo po toksikologii otravliaiushchikh veshchestv. Kiev, 1964.
Stepanov, A. A. “Otravliaiushchie veshchestva.” Zhurnal Vsesoiuznogo khimicheskogo obshchestva imeni D. I. Mendeleeva, 1968, vol. 13, no. 6.



(Ca,Fe,Na)2 A titanian romeite mineral.
(organic chemistry)
C2H2 AsCl3 An oily liquid, colorless to brown or violet; forms a toxic gas, used in World War I.
References in periodicals archive ?
The Allies didn't know it, but German scientists had already evaluated lewisite and concluded it would be ineffective as a weapon.
Some of the recovered materials tested positive for lewisite and its arsenic containing degradation products.
The actual and potential existence of surface contamination by lewisite, mustard gas and ordnance is present at levels above which there are assessed to be moderate risks of adverse effects to health.
Coli, Giardia, and Cryptosporidium, as well as other agents like VX nerve gas, Soman, the blister agent Lewisite, and the biological agents causing Anthrax, Plague, and Smallpox.
The small quantity of GA and lewisite that is stored in bulk containers is being destroyed by the Area 10 liquid incinerator, while a detonation chamber known as the Detonation of Ammunition in a Vacuum-Integrated Chamber (DAVINCH[TM]) is supplementing plant efforts to eliminate the remaining 300-plus overpacked, mustard-filled, 4.
And lastly, while geraniums look pleasant in a bed, Beware their smell in wartime - if it's Lewisite - you're dead.
Some authors regard pederin as a natural mimic of vesicating warfare agents such as mustard and Lewisite.
2]EDTA), British Anti Lewisite (BAL), sodium 2,3-dimercaptopropane 1-sulfonate (DMPS), meso 2,3-dimercaptosuccinic acid (DMSA) etc.
The exclusion criteria for experimental and epidemiologic studies were a) no original research (reviews, editorials, nonresearch letters); b) studies performed only on people with diabetes, including case reports; c) lack of outcomes related to diabetes or glucose metabolism; d) no data on arsenic exposure; e) experiments in nonmammalian cells, or noncellular experiments; f) animal studies administering a single dose of arsenic; and g) culture cell experiments using lewisite or oxophenylarsine.
WASHINGTON, March 17 /PRNewswire/ -- The Department of Veterans Affairs (VA) today announced a national outreach campaign to locate veterans who were exposed to mustard gas or the chemical weapon Lewisite during their service.
The area at Bowes Moor, County Durham is contaminated with mustard gas, phosgene and lewisite, a classified MoD report leaked to the Mirror revealed.
This group of chemical warfare agents includes sulfur mustard, Lewisite [dichloro(2-chlorovinyl)arsine], and nitrogen mustards.