Indirect association studies rely on linkage disequilibrium
(LD) between genetic markers to measure the association between the SNPs genotyped, as well as the SNPs in LD with the assayed site and the disease phenotype (Collins et al.
Patterns of variation in linkage disequilibrium
across loci can be compared with the shape of the clines at those loci.
In the Syn0, linkage disequilibrium
is high and this marker will show a significant effect.
By facilitating differentiation of the subpopulations in the two habitats, isolation by distance helps the buildup of linkage disequilibrium
estimates of contemporary Nc using highly variable genetic markers: a largely untapped resource for applied conservation and evolution.
2] and D' statistical measures reflect different linkage disequilibrium
aspects and show different behaviors under different conditions.
5389A>C were in complete linkage disequilibrium
, and in addition, the g.
Previously published CDH13 genomewide association results and linkage disequilibrium
in the 200-kb GWIS window.
Maize is a cross-pollinated species which exhibits high levels of recombination and a low level of linkage disequilibrium
(Vigouroux et al.
30) In addition, a few variants per gene, usually only one single nucleotide polymorphism (SNP), were examined to evaluate the gene, while tag SNPs for the linkage disequilibrium
(LD) region containing the gene should be examined.
Due to the effects of effective population size on the level of linkage disequilibrium
(Nordborg and Tavare, 2002; Slatkin, 2008), a fast decay of linkage disequilibrium
should be generally expected in marine fishes.
The Hardy-Weinberg equilibrium (HWE) and genotypic linkage disequilibrium
between pairs of microsatellites were tested by Genepop 3.