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linkage disequilibrium

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linkage disequilibrium [¦liŋ·kij dis‚ē·kwə′lib·rē·əm]
(genetics)
The occurrence in a population of certain combinations of linked alleles in greater proportion than expected from the allele frequencies at the loci.
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Researchers from around the world in genomics, microbiology, biostatistics, public health, and other fields discuss such topics as human telomere structure and biology, infectious disease, ENU mutagenesis, the role of enzymes in genetic diseases, linkage disequilibrium and association mapping, legal, ethical, and social issues in genetic testing, DNA sequencing methods, genomic imprinting, and genetic predisposition to breast cancer.
Annual review of genomics and human genetics; v.9, 2008 by SciTech Book News
We grouped SNPs (minor allele frequency >5%) from the European-American CCR samples into bins on the basis of linkage disequilibrium ([r.
Integrating host genomics with surveillance for invasive bacterial ... by Crawford, Dana C.; Zimmer, Shanta M.; Morin, Craig A.; Messonnier, Nancy E.; Lynfield, Ruth; Yi, Qia / Emerging Infectious Diseases
Since then, numerous other studies have attempted to replicate and extend this observation to other populations, but the results have been inconclusive [11, 12] [FIGURE 2 OMITTED] The BsmI polymorphism is in strong linkage disequilibrium with two other polymorphisms also located in the 3' end of the VDR gene: ApaI (in the same intron) and a silent mutation in the ninth exon that alters a TaqI restriction fragment length polymorphism.
The vitamin D receptor gene and osteoporosis by Xuereb-Anastasi, Angela; Vidal, Christopher / Clinical Dermatology
 
 
 
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