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lipofuscin |
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lipofuscin [‚lip·ə′fyüs·ən] (biochemistry) Any of a group of lipid pigments found in cardiac and smooth muscle cells, in macrophages, and in parenchyma and interstitial cells; differential reactions include sudanophilia, Nile blue staining, fatty acid, glycol, and ethylene. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| 55-57) Other reported nucleoside analog-mediated muscle abnormalities have included diminished muscle cell and myoblast (somite cells, which will develop into muscle cells) proliferation (58); increased amounts of intramuscular lipid, glycogen, and lipofuscin (the pigment remaining after the breakdown and digestion of damaged blood cells) (7); and ragged red and necrotic fibers (histological features that are associated with myopathy). In Best's disease, the macula becomes coated with a yellowish substance called lipofuscin, which obstructs progressively larger regions of the retina as an individual ages. Cell culture studies demonstrate the increased accumulation of lipofuscin in cells undergoing oxidative stress and with increasing replicative age, supporting the concept that senescent cells have diminished defenses against oxidative stress (Sitte et al. |
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