lipofuscin


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lipofuscin

[‚lip·ə′fyüs·ən]
(biochemistry)
Any of a group of lipid pigments found in cardiac and smooth muscle cells, in macrophages, and in parenchyma and interstitial cells; differential reactions include sudanophilia, Nile blue staining, fatty acid, glycol, and ethylene.
References in periodicals archive ?
The medication removes the lipid - or fat - deposits, known as lipofuscin, which build up in the back of the eye.
The medication, which is taken orally, removes the lipid - or fat - deposits, known as lipofuscin, which build up in the back of the eye.
Fundus autofluorescence (FAF) is used to study the accumulation of lipofuscin granules within the RPE.
The most prominent cytoplasmic organelles in these cells are smooth endoplasmic reticulum (SER), mitochondria with tubular cristae, lipid droplets, and lipofuscin bodies.
Lipofuscin from poorly functioning retinal pigment epithelium can be observed on the surface of metastatic deposits, which can also be seen in choroidal melanoma.
This pigment displayed staining properties of lipofuscin and melanin, with strong Schmorl positivity as well as strong autofluorescence [Figure 1]a.
It is hoped that, in doing this, these compounds can slow the deterioration that accompanies aging, reduces the accumulation of toxic fluorophores: bis-retinoid N-retinylidene-N-retinylethanolamine (A2E) and lipofuscin, and prevents the loss of photoreceptors and RPE cells.
Originally described by Hermansky and Pudlak in 1959, (77) Hermansky-Pudlak Syndrome (HPS) is caused by a related group of autosomal recessive disorders that are characterized by the triad of oculocutaneous albinism, bleeding diathesis due to a platelet storage pool deficiency, and lysosomal accumulation of ceroid lipofuscin.
Also, the nature of the pigment is different, with colonic pigments being more commonly composed of melanin and lipofuscin, with iron deposits being less common.
RPE lipofuscin and its role in retinal pathobiology.
There was mild anisokaryosis, and perinuclear vacuoles containing lipofuscin granules were widespread.