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loss of heterozygosity

   Also found in: Acronyms, Wikipedia 0.01 sec.
loss of heterozygosity [¦lȯs əv ‚hed·e·rō·zī′gäs·əd·ē]
(genetics)
In a heterozygote, the loss of one of the two alleles at one or more loci in a cell lineage or cancer cell population due to chromosome loss, deletion, or mitotic crossing-over. Abbreviated LOH.


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In the study, Ann Killary from the university and colleagues used a genetic technique termed 'suppression subtractive hybridization' to identify a new gene that is located on Chromosome 1 in a region where loss of heterozygosity (a specific type of genetic alteration) regularly occurs.
49-52 LOSS OF HETEROZYGOSITY Normal human DNA contains 2 alleles for every genetic locus, the majority of which are identical, or homozygous, and the loss of 1 allele results in no pathologic change.
Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro.
 
 
 
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