These data indicate the conserved Taoyuan pig population has suffered a severe loss of heterozygosity
in both mitochondrial and nuclear genomes, and suggest that the population is suffering from inbreeding.
Mechanisms of loss of heterozygosity
in neurofibromatosis type 1-associated plexiform neurofibromas.
In summary, we have demonstrated that an SNP-GMA can detect gains and losses and loss of heterozygosity
of chromosomal material characteristic of malignant melanoma in archived FFPE biopsy specimens with as little as 50 ng of DNA.
Using microarrays to search for tumour gene copy number changes and loss of heterozygosity
actually started a few years ago.
Homozygous deletion on chromosome 9p and loss of heterozygosity
on 9q, 6p, and 6q in primary human small cell lung cancer.
According to previously published research, loss of heterozygosity
(LOH) of certain alleles is a positive predictor for chemotherapeutic response and longer survival rates.
That's how loss of heterozygosity
could turn out to be a valuable shortcut for breeding new rice.
Maynard, MA; 978-897-2800) announced the issuance of its fifth United States Patent 5,928,870, titled "Methods for the Detection of Loss of Heterozygosity
0 will also determine loss of heterozygosity
(LOH), an important genomic change that indicates a loss of normal function that cannot be detected using traditional cytogenetic methods such as FISH or comparative genomic hybridization (CGH).
The PathFinderTG platform assesses loss of heterozygosity
and genetic mutations of multiple tumor suppressor genes.
These were originally termed loss of heterozygosity
(LOH) score, telomeric allelic imbalance (TAI) score, and large scale state transition (LST) score.
The inbreeding coefficient, FIS, reflects the degree of inbreeding in a population by measuring the loss of heterozygosity
within a population.